Entry | Database: PDB / ID: 6p3y |
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Title | Crystal Structure of Full Length APOBEC3G E/Q (pH 7.4) |
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Components | Apolipoprotein B mRNA editing enzyme, catalytic peptide-like 3G |
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Keywords | RNA BINDING PROTEIN / APOBEC3G / HIV / Cytidine Deaminases |
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Function / homology | Function and homology information
Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amidines / DNA cytosine deamination / : / cytidine to uridine editing / cytidine deaminase activity / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / : / retrotransposon silencing / P-body / defense response to virus ...Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In cyclic amidines / DNA cytosine deamination / : / cytidine to uridine editing / cytidine deaminase activity / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / : / retrotransposon silencing / P-body / defense response to virus / ribonucleoprotein complex / innate immune response / RNA binding / zinc ion binding / nucleusSimilarity search - Function Novel AID APOBEC clade 2 / APOBEC/CMP deaminase, zinc-binding / Cytidine and deoxycytidylate deaminases zinc-binding region signature. / Cytidine and deoxycytidylate deaminase domain / Cytidine and deoxycytidylate deaminases domain profile. / Cytidine deaminase-likeSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Macaca mulatta (Rhesus monkey) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.57 Å |
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Authors | Yang, H.J. / Li, S.X. / Chen, X.S. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM087986 | United States |
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Citation | Journal: Nat Commun / Year: 2020 Title: Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G. Authors: Yang, H. / Ito, F. / Wolfe, A.D. / Li, S. / Mohammadzadeh, N. / Love, R.P. / Yan, M. / Zirkle, B. / Gaba, A. / Chelico, L. / Chen, X.S. |
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History | Deposition | May 25, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Feb 12, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 16, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Structure summary Category: audit_author / chem_comp_atom ...audit_author / chem_comp_atom / chem_comp_bond / database_2 / struct_conn / struct_ncs_dom_lim Item: _audit_author.name / _database_2.pdbx_DOI ..._audit_author.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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