登録情報 データベース : PDB / ID : 6p3p 構造の表示 ダウンロードとリンクタイトル Crystal structure of Mcl-1 in complex with compound 65 要素Induced myeloid leukemia cell differentiation protein Mcl-1 詳細 キーワード APOPTOSIS/APOPTOSIS INHIBITOR / Mcl-1 / biaryl sulfonamide inhibitor / APOPTOSIS-APOPTOSIS INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / 拘束 (生物学) / mitochondrial fusion / channel activity / Bcl-2 family protein complex / BH3 domain binding / protein transmembrane transporter activity / negative regulation of anoikis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ... positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / 拘束 (生物学) / mitochondrial fusion / channel activity / Bcl-2 family protein complex / BH3 domain binding / protein transmembrane transporter activity / negative regulation of anoikis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / intrinsic apoptotic signaling pathway in response to DNA damage / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / protein homodimerization activity / ミトコンドリア / 核質 / 生体膜 / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions ... Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2ファミリー / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Bcl-2ファミリー / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-NQJ / Induced myeloid leukemia cell differentiation protein Mcl-1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.61 Å 詳細データ登録者 Toms, A.V. / Follows, B. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2019タイトル : Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.著者 : Follows, B. / Fessler, S. / Baumeister, T. / Campbell, A.M. / Zablocki, M.M. / Li, H. / Gotur, D. / Wang, Z. / Zheng, X. / Molz, L. / Nguyen, C. / Herbertz, T. / Wang, L. / Bair, K. 履歴 登録 2019年5月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年7月3日 Provider : repository / タイプ : Initial release改定 1.1 2019年7月10日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ... _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2019年8月21日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2023年10月11日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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