登録情報 | データベース: PDB / ID: 6oia |
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タイトル | (1S,3S)-3-amino-4-(perfluoropropan-2-ylidene)cyclopentane-1-carboxylic acid hydrochloride, a potent inhibitor of ornithine aminotransferase |
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要素 | Ornithine aminotransferase, mitochondrial |
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キーワード | TRANSFERASE / Human Ornithine Aminotransferase (hOAT) Mechanism Based Inhibitors Hepatocellular Carcinoma PLP |
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機能・相同性 | 機能・相同性情報
arginine catabolic process to proline via ornithine / ornithine aminotransferase activity / ornithine aminotransferase / arginine catabolic process to glutamate / L-proline biosynthetic process / Glutamate and glutamine metabolism / visual perception / pyridoxal phosphate binding / mitochondrial matrix / mitochondrion ...arginine catabolic process to proline via ornithine / ornithine aminotransferase activity / ornithine aminotransferase / arginine catabolic process to glutamate / L-proline biosynthetic process / Glutamate and glutamine metabolism / visual perception / pyridoxal phosphate binding / mitochondrial matrix / mitochondrion / nucleoplasm / identical protein binding / cytoplasm類似検索 - 分子機能 Ornithine aminotransferase / : / Aminotransferases class-III pyridoxal-phosphate attachment site. / Aminotransferase class-III / Aminotransferase class-III / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase; domain 2 / Type I PLP-dependent aspartate aminotransferase-like (Major domain) / Pyridoxal phosphate-dependent transferase, small domain ...Ornithine aminotransferase / : / Aminotransferases class-III pyridoxal-phosphate attachment site. / Aminotransferase class-III / Aminotransferase class-III / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase; domain 2 / Type I PLP-dependent aspartate aminotransferase-like (Major domain) / Pyridoxal phosphate-dependent transferase, small domain / Pyridoxal phosphate-dependent transferase, major domain / Pyridoxal phosphate-dependent transferase / Alpha-Beta Complex / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-MQ4 / PYRIDOXAL-5'-PHOSPHATE / Ornithine aminotransferase, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.777 Å |
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データ登録者 | Catlin, D.S. / Liu, D. / Moschitto, M.J. / Doubleday, P.F. / Kelleher, N. / Silverman, R.B. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | | 米国 |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2019 タイトル: Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid. 著者: Moschitto, M.J. / Doubleday, P.F. / Catlin, D.S. / Kelleher, N.L. / Liu, D. / Silverman, R.B. |
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履歴 | 登録 | 2019年4月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年9月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support Item: _pdbx_audit_support.country / _pdbx_audit_support.funding_organization |
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改定 1.2 | 2020年4月1日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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