DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3')
DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3')
Methyl-CpG-binding protein 2
Keywords
DNA BINDING PROTEIN/DNA / MBD / Structural Genomics / Structural Genomics Consortium / SGC / DNA BINDING PROTEIN-DNA complex
Function / homology
Function and homology information
trans-synaptic signaling by BDNF / regulation of action potential firing threshold / negative regulation of respiratory gaseous exchange / Loss of MECP2 binding ability to 5hmC-DNA / cellular response to isoquinoline alkaloid / positive regulation of anterograde dense core granule transport / positive regulation of retrograde dense core granule transport / positive regulation of branching morphogenesis of a nerve / catecholamine secretion / MECP2 regulates transcription of genes involved in GABA signaling ...trans-synaptic signaling by BDNF / regulation of action potential firing threshold / negative regulation of respiratory gaseous exchange / Loss of MECP2 binding ability to 5hmC-DNA / cellular response to isoquinoline alkaloid / positive regulation of anterograde dense core granule transport / positive regulation of retrograde dense core granule transport / positive regulation of branching morphogenesis of a nerve / catecholamine secretion / MECP2 regulates transcription of genes involved in GABA signaling / biogenic amine metabolic process / principal sensory nucleus of trigeminal nerve development / cardiolipin metabolic process / negative regulation of dendrite extension / negative regulation of locomotion involved in locomotory behavior / MECP2 regulates transcription factors / Loss of MECP2 binding ability to 5mC-DNA / nervous system process involved in regulation of systemic arterial blood pressure / proprioception / negative regulation of primary miRNA processing / MECP2 regulates transcription of neuronal ligands / negative regulation of smooth muscle cell differentiation / Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of dendritic spine development / Transcriptional Regulation by MECP2 / regulation of respiratory gaseous exchange by nervous system process / double-stranded methylated DNA binding / ventricular cardiac muscle tissue development / inositol metabolic process / genomic imprinting / phosphatidylcholine metabolic process / thalamus development / positive regulation of microtubule nucleation / glucocorticoid metabolic process / ventricular system development / cellular response to potassium ion / unmethylated CpG binding / positive regulation of synaptic plasticity / respiratory gaseous exchange by respiratory system / oligodendrocyte development / olfactory bulb development / positive regulation of dendrite extension / striatum development / response to other organism / siRNA binding / neuron maturation / methyl-CpG binding / negative regulation of blood vessel endothelial cell migration / Loss of phosphorylation of MECP2 at T308 / negative regulation of gene expression via chromosomal CpG island methylation / response to ionizing radiation / spinal cord development / positive regulation of dendritic spine development / lung alveolus development / regulation of synapse organization / histone reader activity / glutamine metabolic process / startle response / dendrite development / positive regulation of glial cell proliferation / social behavior / Regulation of MECP2 expression and activity / negative regulation of astrocyte differentiation / behavioral fear response / glial cell proliferation / heterochromatin / long-term memory / Nuclear events stimulated by ALK signaling in cancer / negative regulation of angiogenesis / MECP2 regulates neuronal receptors and channels / four-way junction DNA binding / Notch signaling pathway / sensory perception of pain / synapse assembly / cerebellum development / adult locomotory behavior / excitatory postsynaptic potential / post-embryonic development / molecular condensate scaffold activity / response to cocaine / promoter-specific chromatin binding / hippocampus development / long-term synaptic potentiation / response to lead ion / visual learning / heterochromatin formation / chromatin DNA binding / cerebral cortex development / histone deacetylase binding / transcription corepressor activity / protein localization / response to estradiol / gene expression / nucleic acid binding / negative regulation of neuron apoptotic process / postsynapse / molecular adaptor activity / response to hypoxia / protein domain specific binding / negative regulation of gene expression Similarity search - Function
Methyl-CpG binding protein MeCP2 / Methyl-cpg-binding Protein 2; Chain A / Methyl-cpg-binding Protein 2; Chain A / Methyl-CpG binding protein MeCP2/MBD4 / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. / DNA-binding domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
A: Methyl-CpG-binding protein 2 D: DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3') C: DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3') hetero molecules
Resolution: 1.65→40.9 Å / Cor.coef. Fo:Fc: 0.954 / Cor.coef. Fo:Fc free: 0.944 / SU B: 6.003 / SU ML: 0.099 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.125 / ESU R Free: 0.119 Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : WITH TLS ADDED
Rfactor
Num. reflection
% reflection
Rfree
0.2552
1773
10.2 %
Rwork
0.2259
-
-
obs
0.2289
15648
99.96 %
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å
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