Entry Database : PDB / ID : 6oda Structure visualization Downloads & linksTitle Crystal structure of HDAC8 in complex with compound 2 ComponentsHistone deacetylase 8 Details Keywords HYDROLASE / histone deacetylase / HDAC8 / hydroxamic acidFunction / homology Function and homology informationFunction Domain/homology Component
histone decrotonylase activity / histone deacetylase / protein lysine deacetylase activity / regulation of telomere maintenance / Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides / mitotic sister chromatid cohesion / histone deacetylase activity / nuclear chromosome / Notch-HLH transcription pathway / histone deacetylase complex ... histone decrotonylase activity / histone deacetylase / protein lysine deacetylase activity / regulation of telomere maintenance / Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides / mitotic sister chromatid cohesion / histone deacetylase activity / nuclear chromosome / Notch-HLH transcription pathway / histone deacetylase complex / negative regulation of protein ubiquitination / Resolution of Sister Chromatid Cohesion / Hsp70 protein binding / HDACs deacetylate histones / Hsp90 protein binding / regulation of protein stability / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / Separation of Sister Chromatids / chromatin organization / DNA-binding transcription factor binding / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytoplasm Similarity search - Function Histone deacetylase / Histone deacetylase domain / Arginase; Chain A / Histone deacetylase family / Histone deacetylase domain / Histone deacetylase domain superfamily / Histone deacetylase domain / Ureohydrolase domain superfamily / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.88 Å DetailsAuthors Zheng, X. / Conti, C. / Caravella, J. / Zablocki, M.-M. / Bair, K. / Barczak, N. / Han, B. / Lancia Jr., D. / Liu, C. / Martin, M. ...Zheng, X. / Conti, C. / Caravella, J. / Zablocki, M.-M. / Bair, K. / Barczak, N. / Han, B. / Lancia Jr., D. / Liu, C. / Martin, M. / Ng, P.Y. / Rudnitskaya, A. / Thomason, J.J. / Garcia-Dancey, R. / Hardy, C. / Lahdenranta, J. / Leng, C. / Li, P. / Pardo, E. / Saldahna, A. / Tan, T. / Toms, A.V. / Yao, L. / Zhang, C. CitationJournal : To Be Published Title : Structure-based Discovery of Novel N-(E)-N-Hydroxy-3-(2-(2-oxoimidazolidin-1-yl)phenyl)acrylamides as Potent and Selective HDAC8 inhibitorsAuthors: Zheng, X. / Conti, C. / Caravella, J. / Zablocki, M.-M. / Bair, K. / Barczak, N. / Han, B. / Lancia Jr., D. / Liu, C. / Martin, M. / Ng, P.Y. / Rudnitskaya, A. / Thomason, J.J. / Garcia- ... Authors : Zheng, X. / Conti, C. / Caravella, J. / Zablocki, M.-M. / Bair, K. / Barczak, N. / Han, B. / Lancia Jr., D. / Liu, C. / Martin, M. / Ng, P.Y. / Rudnitskaya, A. / Thomason, J.J. / Garcia-Dancey, R. / Hardy, C. / Lahdenranta, J. / Leng, C. / Li, P. / Pardo, E. / Saldahna, A. / Tan, T. / Toms, A.V. / Yao, L. / Zhang, C. History Deposition Mar 26, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 1, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Oct 11, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
Show all Show less