登録情報 | データベース: PDB / ID: 6ne5 |
---|
タイトル | Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer |
---|
要素 | Induced myeloid leukemia cell differentiation protein Mcl-1 |
---|
キーワード | APOPTOSIS / structure based drug discovery / cancer / Mcl-1 / drug discovery |
---|
機能・相同性 | 機能・相同性情報
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / mitochondrial fusion / Bcl-2 family protein complex / BH3 domain binding / negative regulation of anoikis / protein transmembrane transporter activity / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway in absence of ligand ...positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cell fate determination / cellular homeostasis / mitochondrial fusion / Bcl-2 family protein complex / BH3 domain binding / negative regulation of anoikis / protein transmembrane transporter activity / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway in absence of ligand / response to cytokine / negative regulation of autophagy / release of cytochrome c from mitochondria / intrinsic apoptotic signaling pathway in response to DNA damage / Signaling by ALK fusions and activated point mutants / positive regulation of neuron apoptotic process / channel activity / Interleukin-4 and Interleukin-13 signaling / regulation of apoptotic process / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / mitochondrion / nucleoplasm / nucleus / membrane / cytosol / cytoplasm類似検索 - 分子機能 Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / Bcl-2 family ...Apoptosis regulator, Mcl-1 / Blc2-like / Apoptosis Regulator Bcl-x / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / Bcl-2 family / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl2-like / Bcl-2, Bcl-2 homology region 1-3 / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-KJP / Induced myeloid leukemia cell differentiation protein Mcl-1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.85 Å |
---|
データ登録者 | Zhao, B. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Cancer Institute (NIH/NCI) | HHSN261200800001E | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | P50CA098131 | 米国 |
|
---|
引用 | ジャーナル: J.Med.Chem. / 年: 2019 タイトル: Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. 著者: Lee, T. / Christov, P.P. / Shaw, S. / Tarr, J.C. / Zhao, B. / Veerasamy, N. / Jeon, K.O. / Mills, J.J. / Bian, Z. / Sensintaffar, J.L. / Arnold, A.L. / Fogarty, S.A. / Perry, E. / Ramsey, H.E. ...著者: Lee, T. / Christov, P.P. / Shaw, S. / Tarr, J.C. / Zhao, B. / Veerasamy, N. / Jeon, K.O. / Mills, J.J. / Bian, Z. / Sensintaffar, J.L. / Arnold, A.L. / Fogarty, S.A. / Perry, E. / Ramsey, H.E. / Cook, R.S. / Hollingshead, M. / Davis Millin, M. / Lee, K.M. / Koss, B. / Budhraja, A. / Opferman, J.T. / Kim, K. / Arteaga, C.L. / Moore, W.J. / Olejniczak, E.T. / Savona, M.R. / Fesik, S.W. |
---|
履歴 | 登録 | 2018年12月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2019年4月17日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2019年5月8日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_ISSN ..._citation.journal_abbrev / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name |
---|
改定 1.2 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|