Entry Database : PDB / ID : 6i6r Structure visualization Downloads & linksTitle New Irreversible a-l-Iduronidase Inhibitors and Activity-Based Probes ComponentsAlpha-L-iduronidase Details Keywords HYDROLASE / Iduronidase Inhibitors GH39Function / homology Function and homology informationFunction Domain/homology Component
L-iduronidase / L-iduronidase activity / disaccharide metabolic process / MPS I - Hurler syndrome / heparin catabolic process / dermatan sulfate catabolic process / glycosaminoglycan catabolic process / CS/DS degradation / heparan sulfate proteoglycan catabolic process / HS-GAG degradation ... L-iduronidase / L-iduronidase activity / disaccharide metabolic process / MPS I - Hurler syndrome / heparin catabolic process / dermatan sulfate catabolic process / glycosaminoglycan catabolic process / CS/DS degradation / heparan sulfate proteoglycan catabolic process / HS-GAG degradation / lysosomal lumen / signaling receptor binding / extracellular exosome Similarity search - Function : / Alpha-L-iduronidase C-terminal domain / Glycosyl hydrolase domain; family 39 / : / : / Glycosyl hydrolases family 39 active site. / Glycoside hydrolase, family 39 / Glycosyl hydrolases family 39 / Glycosidases / Glycoside hydrolase superfamily ... : / Alpha-L-iduronidase C-terminal domain / Glycosyl hydrolase domain; family 39 / : / : / Glycosyl hydrolases family 39 active site. / Glycoside hydrolase, family 39 / Glycosyl hydrolases family 39 / Glycosidases / Glycoside hydrolase superfamily / Immunoglobulins / TIM Barrel / Alpha-Beta Barrel / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.02 Å DetailsAuthors Gloster, T.M. / McMahon, S.A. / Oehler, V. CitationJournal : Chemistry / Year : 2018Title : New Irreversible alpha-l-Iduronidase Inhibitors and Activity-Based Probes.Authors: Artola, M. / Kuo, C.L. / McMahon, S.A. / Oehler, V. / Hansen, T. / van der Lienden, M. / He, X. / van den Elst, H. / Florea, B.I. / Kermode, A.R. / van der Marel, G.A. / Gloster, T.M. / ... Authors : Artola, M. / Kuo, C.L. / McMahon, S.A. / Oehler, V. / Hansen, T. / van der Lienden, M. / He, X. / van den Elst, H. / Florea, B.I. / Kermode, A.R. / van der Marel, G.A. / Gloster, T.M. / Codee, J.D.C. / Overkleeft, H.S. / Aerts, J.M.F.G. History Deposition Nov 15, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 5, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Dec 26, 2018 Group : Data collection / Database references / Category : citation / citation_author / pdbx_database_procItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID Revision 1.2 Mar 6, 2019 Group : Data collection / Category : reflns / Item : _reflns.pdbx_Rmerge_I_obsRevision 1.3 Aug 14, 2019 Group : Data collection / Category : reflns / Item : _reflns.pdbx_Rrim_I_allRevision 2.0 Jul 29, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_validate_close_contact / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.src_method / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Jan 24, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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