- PDB-6i3y: Crystal structure of the human mitochondrial PRELID1K58V-TRIAP1 c... -
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基本情報
登録情報
データベース: PDB / ID: 6i3y
タイトル
Crystal structure of the human mitochondrial PRELID1K58V-TRIAP1 complex with PS
要素
PRELI domain-containing protein 1, mitochondrial
TP53-regulated inhibitor of apoptosis 1
キーワード
LIPID TRANSPORT / Mitochondrial lipid transport / Complex / Phosphatidylserine bound / PA transport / Apoptosis
機能・相同性
機能・相同性情報
regulation of membrane lipid distribution / positive regulation of phospholipid transport / positive regulation of endopeptidase activity / positive regulation of cellular respiration / intermembrane lipid transfer / phospholipid transport / positive regulation of T cell apoptotic process / regulation of T cell differentiation / phospholipid translocation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ...regulation of membrane lipid distribution / positive regulation of phospholipid transport / positive regulation of endopeptidase activity / positive regulation of cellular respiration / intermembrane lipid transfer / phospholipid transport / positive regulation of T cell apoptotic process / regulation of T cell differentiation / phospholipid translocation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / negative regulation of release of cytochrome c from mitochondria / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / negative regulation of mitochondrial membrane potential / mitotic G1 DNA damage checkpoint signaling / regulation of mitochondrial membrane potential / Mitochondrial protein degradation / DNA damage response, signal transduction by p53 class mediator / mitochondrial intermembrane space / cellular response to UV / p53 binding / apoptotic process / negative regulation of apoptotic process / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / nucleoplasm / nucleus 類似検索 - 分子機能
PRELI/MSF1 domain / Slowmo/Ups family / PRELI-like family / PRELI/MSF1 domain profile. / Mitochondrial distribution/morphology family 35/apoptosis / Uncharacterised protein family (UPF0203) / Coiled coil-helix-coiled coil-helix (CHCH) domain profile. 類似検索 - ドメイン・相同性
Chem-P5S / TP53-regulated inhibitor of apoptosis 1 / PRELI domain-containing protein 1, mitochondrial 類似検索 - 構成要素
C: PRELI domain-containing protein 1, mitochondrial H: TP53-regulated inhibitor of apoptosis 1 ヘテロ分子
F: PRELI domain-containing protein 1, mitochondrial A: TP53-regulated inhibitor of apoptosis 1 ヘテロ分子
登録者・ソフトウェアが定義した集合体
根拠: mass spectrometry, Lipidomics and native mass spectrometry used to confirm substrate binding. DOPS was exchanged to 25% in the PRELIK58V sample (see supplementary materials) upon incubation of 10X (6:3) DDM-DOPS.
解像度: 2.98→63 Å / Cor.coef. Fo:Fc: 0.942 / Cor.coef. Fo:Fc free: 0.927 / SU B: 28.173 / SU ML: 0.471 / 交差検証法: THROUGHOUT / ESU R: 1.311 / ESU R Free: 0.436 / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS