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Yorodumi- PDB-6hpi: NMR structure of the pro-inflammatory cytokine interleukin-36alpha -
+Open data
-Basic information
Entry | Database: PDB / ID: 6hpi | ||||||
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Title | NMR structure of the pro-inflammatory cytokine interleukin-36alpha | ||||||
Components | Interleukin-36 alpha | ||||||
Keywords | CYTOKINE / PROTEIN INTERLEUKIN-1 SUPERFAMILY BETA-TREFOIL HEME-BINDING | ||||||
Function / homology | Function and homology information Interleukin-36 pathway / interleukin-1 receptor binding / inflammatory response to antigenic stimulus / cytokine activity / cytokine-mediated signaling pathway / cellular response to lipopolysaccharide / immune response / inflammatory response / innate immune response / positive regulation of gene expression ...Interleukin-36 pathway / interleukin-1 receptor binding / inflammatory response to antigenic stimulus / cytokine activity / cytokine-mediated signaling pathway / cellular response to lipopolysaccharide / immune response / inflammatory response / innate immune response / positive regulation of gene expression / extracellular space / extracellular region / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / molecular dynamics | ||||||
Authors | Ohlenschlaeger, O. / Imhof, D. | ||||||
Funding support | Germany, 1items
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Citation | Journal: Biomol NMR Assign / Year: 2016 Title: (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha. Authors: Goradia, N. / Wissbrock, A. / Wiedemann, C. / Bordusa, F. / Ramachandran, R. / Imhof, D. / Ohlenschlaeger, O. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6hpi.cif.gz | 959 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6hpi.ent.gz | 805.2 KB | Display | PDB format |
PDBx/mmJSON format | 6hpi.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/hp/6hpi ftp://data.pdbj.org/pub/pdb/validation_reports/hp/6hpi | HTTPS FTP |
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-Related structure data
Similar structure data | |
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Other databases |
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 17702.379 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: IL36A, FIL1E, IL1E, IL1F6 / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: Q9UHA7 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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Sample |
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Sample conditions | Ionic strength: 0 M / Label: sample_conditions_1 / pH: 6.9 / Pressure: 1 atm / Temperature: 273 K |
-NMR measurement
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Method: molecular dynamics / Software ordinal: 1 / Details: energy minimisation | |||||||||||||||
NMR representative | Selection criteria: closest to the average | |||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the least restraint violations Conformers calculated total number: 100 / Conformers submitted total number: 20 |