登録情報 | データベース: PDB / ID: 6ghp |
---|
タイトル | 14-3-3sigma in complex with a TASK3 peptide stabilized by semi-synthetic natural product FC-NAc |
---|
要素 | - 14-3-3 protein sigma
- Potassium channel subfamily K member 9
|
---|
キーワード | SIGNALING PROTEIN / Potassium channel / natural product / PPI / stabilizer |
---|
機能・相同性 | 機能・相同性情報
TWIK-releated acid-sensitive K+ channel (TASK) / Phase 4 - resting membrane potential / stabilization of membrane potential / potassium ion leak channel activity / outward rectifier potassium channel activity / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization ...TWIK-releated acid-sensitive K+ channel (TASK) / Phase 4 - resting membrane potential / stabilization of membrane potential / potassium ion leak channel activity / outward rectifier potassium channel activity / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / potassium channel activity / potassium ion import across plasma membrane / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / potassium ion transmembrane transport / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / potassium ion transport / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / synaptic vesicle / positive regulation of cell growth / regulation of cell cycle / cadherin binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Potassium channel subfamily K member 9 / Two pore domain potassium channel, TASK family / Two pore domain potassium channel / 14-3-3 domain / Delta-Endotoxin; domain 1 / Potassium channel domain / Ion channel / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site ...Potassium channel subfamily K member 9 / Two pore domain potassium channel, TASK family / Two pore domain potassium channel / 14-3-3 domain / Delta-Endotoxin; domain 1 / Potassium channel domain / Ion channel / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-EZ5 / 14-3-3 protein sigma / Potassium channel subfamily K member 9類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / 分子置換 / 解像度: 1.95 Å |
---|
データ登録者 | Andrei, S.A. / de Vink, P.J. / Brunsveld, L. / Ottmann, C. / Higuchi, Y. |
---|
資金援助 | オランダ, 日本, 4件 組織 | 認可番号 | 国 |
---|
Netherlands Organisation for Scientific Research | ECHO -STIP 717.014.001 | オランダ | Netherlands Organisation for Scientific Research | Gravity program 024.001.035 | オランダ | Japan Society for the Promotion of Science | KAKENHI Grant JP 16K21138 | 日本 | Japan Agency for Medical Research and Development (AMED) | Platform Project for Supporting Drug Discovery and Life Science Research | 日本 |
|
---|
引用 | ジャーナル: Angew. Chem. Int. Ed. Engl. / 年: 2018 タイトル: Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions. 著者: Andrei, S.A. / de Vink, P. / Sijbesma, E. / Han, L. / Brunsveld, L. / Kato, N. / Ottmann, C. / Higuchi, Y. |
---|
履歴 | 登録 | 2018年5月8日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2018年8月1日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2018年10月17日 | Group: Data collection / Database references / Structure summary カテゴリ: citation / citation_author / entity Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID / _citation_author.name / _entity.formula_weight |
---|
|
---|