登録情報 | データベース: PDB / ID: 6g0v |
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タイトル | Human Galectin-3 in complex with a TF tumor-associated antigen mimetic |
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要素 | Galectin-3 |
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キーワード | CELL ADHESION / Galectin-3 / Thomsen-Friedenreich / tumour antigen / cancer / TF-mimetic |
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機能・相同性 | 機能・相同性情報
: / negative regulation of immunological synapse formation / disaccharide binding / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / RUNX2 regulates genes involved in differentiation of myeloid cells / regulation of T cell apoptotic process / mononuclear cell migration / positive regulation of mononuclear cell migration / negative regulation of endocytosis / IgE binding ...: / negative regulation of immunological synapse formation / disaccharide binding / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / RUNX2 regulates genes involved in differentiation of myeloid cells / regulation of T cell apoptotic process / mononuclear cell migration / positive regulation of mononuclear cell migration / negative regulation of endocytosis / IgE binding / eosinophil chemotaxis / regulation of extrinsic apoptotic signaling pathway via death domain receptors / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / protein phosphatase inhibitor activity / negative regulation of T cell receptor signaling pathway / regulation of T cell proliferation / positive chemotaxis / macrophage chemotaxis / positive regulation of calcium ion import / chemoattractant activity / monocyte chemotaxis / Advanced glycosylation endproduct receptor signaling / ficolin-1-rich granule membrane / immunological synapse / laminin binding / epithelial cell differentiation / neutrophil chemotaxis / RNA splicing / secretory granule membrane / molecular condensate scaffold activity / negative regulation of extrinsic apoptotic signaling pathway / positive regulation of protein localization to plasma membrane / spliceosomal complex / positive regulation of protein-containing complex assembly / mRNA processing / carbohydrate binding / protein phosphatase binding / collagen-containing extracellular matrix / mitochondrial inner membrane / innate immune response / Neutrophil degranulation / cell surface / RNA binding / extracellular space / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Galectin-like / Galactoside-binding lectin / Galectin / Galectin, carbohydrate recognition domain / Galactoside-binding lectin / Galactoside-binding lectin (galectin) domain profile. / Jelly Rolls - #200 / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.09 Å |
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データ登録者 | Trovao, F.G. / Santarsia, S. / Carvalho, A.L. |
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資金援助 | ポルトガル, 2件 組織 | 認可番号 | 国 |
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FEDER | POCI-01-0145-FEDER-007728 | ポルトガル | FCT/MCTES | UID/Multi/04378/2013 | ポルトガル |
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引用 | ジャーナル: ChemMedChem / 年: 2018 タイトル: Molecular Recognition of a Thomsen-Friedenreich Antigen Mimetic Targeting Human Galectin-3. 著者: Santarsia, S. / Grosso, A.S. / Trovao, F. / Jimenez-Barbero, J. / Carvalho, A.L. / Nativi, C. / Marcelo, F. |
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履歴 | 登録 | 2018年3月19日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年8月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年10月17日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2024年5月8日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / refine_hist Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.d_res_high |
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