ジャーナル: Curr Opin Virol / 年: 2020 タイトル: Virion structures and genome delivery of honeybee viruses. 著者: Michaela Procházková / Karel Škubník / Tibor Füzik / Liya Mukhamedova / Antonín Přidal / Pavel Plevka / 要旨: The western honeybee is the primary pollinator of numerous food crops. Furthermore, honeybees are essential for ecosystem stability by sustaining the diversity and abundance of wild flowering plants. ...The western honeybee is the primary pollinator of numerous food crops. Furthermore, honeybees are essential for ecosystem stability by sustaining the diversity and abundance of wild flowering plants. However, the worldwide population of honeybees is under pressure from environmental stress and pathogens. Viruses from the families Iflaviridae and Dicistroviridae, together with their vector, the parasitic mite Varroa destructor, are the major threat to the world's honeybees. Dicistroviruses and iflaviruses have capsids with icosahedral symmetries. Acidic pH triggers the genome release of both dicistroviruses and iflaviruses. The capsids of iflaviruses expand, whereas those of dicistroviruses remain compact until the genome release. Furthermore, dicistroviruses use inner capsid proteins, whereas iflaviruses employ protruding domains or minor capsid proteins from the virion surface to penetrate membranes and deliver their genomes into the cell cytoplasm. The structural characterization of the infection process opens up possibilities for the development of antiviral compounds.
履歴
登録
2017年12月1日
登録サイト: PDBE / 処理サイト: PDBE
改定 1.0
2018年12月12日
Provider: repository / タイプ: Initial release
改定 1.1
2019年7月31日
Group: Data collection / Refinement description / カテゴリ: refine