登録情報 データベース : PDB / ID : 6eqm 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Human BACE-1 in Complex with CNP520 要素Beta-secretase 1 詳細 キーワード HYDROLASE / Structure-based drug design / Alzheimer's disease / aspartic acid proteinase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / detection of mechanical stimulus involved in sensory perception of pain ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / detection of mechanical stimulus involved in sensory perception of pain / prepulse inhibition / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / protein processing / recycling endosome / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 1.35 Å 詳細データ登録者 Rondeau, J.-M. / Wirth, E. 引用ジャーナル : EMBO Mol Med / 年 : 2018タイトル : The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.著者: Neumann, U. / Ufer, M. / Jacobson, L.H. / Rouzade-Dominguez, M.L. / Huledal, G. / Kolly, C. / Luond, R.M. / Machauer, R. / Veenstra, S.J. / Hurth, K. / Rueeger, H. / Tintelnot-Blomley, M. / ... 著者 : Neumann, U. / Ufer, M. / Jacobson, L.H. / Rouzade-Dominguez, M.L. / Huledal, G. / Kolly, C. / Luond, R.M. / Machauer, R. / Veenstra, S.J. / Hurth, K. / Rueeger, H. / Tintelnot-Blomley, M. / Staufenbiel, M. / Shimshek, D.R. / Perrot, L. / Frieauff, W. / Dubost, V. / Schiller, H. / Vogg, B. / Beltz, K. / Avrameas, A. / Kretz, S. / Pezous, N. / Rondeau, J.M. / Beckmann, N. / Hartmann, A. / Vormfelde, S. / David, O.J. / Galli, B. / Ramos, R. / Graf, A. / Lopez Lopez, C. 履歴 登録 2017年10月13日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2018年9月19日 Provider : repository / タイプ : Initial release改定 1.1 2018年9月26日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_abbrev / _citation.pdbx_database_id_PubMed / _citation.title改定 1.2 2018年11月21日 Group : Data collection / Database referencesカテゴリ : citation / citation_author / pdbx_database_procItem : _citation.journal_volume / _citation_author.identifier_ORCID改定 1.3 2024年5月1日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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