Entry Database : PDB / ID : 6bz3 Structure visualization Downloads & linksTitle Complex structure of FAK FAT domain and DCC P3 motif ComponentsFocal adhesion kinase 1 Netrin receptor DCC DetailsKeywords TRANSFERASE/MEMBRANE PROTEIN / 4-helix bundle / axon guidance / focal adhesion kinase / transferase-peptide complex / MEMBRANE PROTEIN / TRANSFERASE-MEMBRANE PROTEIN complexFunction / homology Function and homology informationFunction Domain/homology Component
Netrin-1 signaling / DCC mediated attractive signaling / Caspase activation via Dependence Receptors in the absence of ligand / DCC mediated attractive signaling / Apoptotic cleavage of cellular proteins / netrin receptor activity / dorsal/ventral axon guidance / MET activates PTK2 signaling / NCAM signaling for neurite out-growth / spinal cord ventral commissure morphogenesis ... Netrin-1 signaling / DCC mediated attractive signaling / Caspase activation via Dependence Receptors in the absence of ligand / DCC mediated attractive signaling / Apoptotic cleavage of cellular proteins / netrin receptor activity / dorsal/ventral axon guidance / MET activates PTK2 signaling / NCAM signaling for neurite out-growth / spinal cord ventral commissure morphogenesis / negative regulation of synapse assembly / anterior/posterior axon guidance / central nervous system neuron axonogenesis / EPHB-mediated forward signaling / RHO GTPases Activate WASPs and WAVEs / GRB2:SOS provides linkage to MAPK signaling for Integrins / Integrin signaling / p130Cas linkage to MAPK signaling for integrins / Extra-nuclear estrogen signaling / RAF/MAP kinase cascade / intracellular chloride ion homeostasis / negative regulation of axonogenesis / growth cone membrane / Regulation of actin dynamics for phagocytic cup formation / negative regulation of organ growth / corpus callosum development / regulation of modification of postsynaptic actin cytoskeleton / positive regulation of ubiquitin-dependent protein catabolic process / VEGFA-VEGFR2 Pathway / signal complex assembly / nuclear migration / regulation of osteoblast differentiation / optic nerve development / organ growth / postsynaptic modulation of chemical synaptic transmission / axon development / positive regulation of cardiac muscle hypertrophy / blood vessel development / positive regulation of smooth muscle cell migration / regulation of cell adhesion mediated by integrin / positive regulation of cell adhesion / intercalated disc / endothelial cell migration / ephrin receptor signaling pathway / positive regulation of protein kinase activity / phosphatase binding / vasculogenesis / positive regulation of synaptic transmission / regulation of cell adhesion / phosphatidylinositol 3-kinase binding / axonal growth cone / positive regulation of phagocytosis / positive regulation of glial cell proliferation / JNK cascade / cellular response to transforming growth factor beta stimulus / response to amphetamine / negative regulation of autophagy / negative regulation of cell migration / extracellular matrix organization / axonogenesis / ciliary basal body / integrin-mediated signaling pathway / postsynaptic density membrane / positive regulation of smooth muscle cell proliferation / axon guidance / non-specific protein-tyrosine kinase / neuron migration / non-membrane spanning protein tyrosine kinase activity / Schaffer collateral - CA1 synapse / epidermal growth factor receptor signaling pathway / cerebral cortex development / sarcolemma / positive regulation of neuron projection development / cell-cell adhesion / microtubule cytoskeleton organization / peptidyl-tyrosine phosphorylation / vasodilation / MAPK cascade / cell migration / integrin binding / lamellipodium / regulation of cell population proliferation / cell cortex / regulation of cell shape / positive regulation of cell growth / postsynapse / basolateral plasma membrane / protein tyrosine kinase activity / angiogenesis / protein autophosphorylation / dendritic spine / transcription coactivator activity / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / nuclear body / positive regulation of cell migration / positive regulation of protein phosphorylation / apical plasma membrane / axon / focal adhesion Similarity search - Function Neogenin, C-terminal / Neogenin C-terminus / Nucleotidyltransferases domain 2 / Focal adhesion kinase, targeting (FAT) domain / Focal adhesion kinase, targeting (FAT) domain superfamily / Focal adhesion kinase, N-terminal / FAK1/PYK2, FERM domain C-lobe / Focal adhesion targeting region / FERM N-terminal domain / : ... Neogenin, C-terminal / Neogenin C-terminus / Nucleotidyltransferases domain 2 / Focal adhesion kinase, targeting (FAT) domain / Focal adhesion kinase, targeting (FAT) domain superfamily / Focal adhesion kinase, N-terminal / FAK1/PYK2, FERM domain C-lobe / Focal adhesion targeting region / FERM N-terminal domain / : / FAK1/PYK2, FERM domain C-lobe / FERM domain signature 2. / Immunoglobulin domain / FERM central domain / FERM/acyl-CoA-binding protein superfamily / FERM central domain / FERM superfamily, second domain / FERM domain / FERM domain profile. / Band 4.1 domain / Band 4.1 homologues / Immunoglobulin I-set / Immunoglobulin I-set domain / Four Helix Bundle (Hemerythrin (Met), subunit A) / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ubiquitin-like domain superfamily / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.497 Å DetailsAuthors Xu, S. / Wang, J.-H. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) P01HL103526 United States
CitationJournal : Cell Discov / Year : 2018Title : The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction.Authors : Xu, S. / Liu, Y. / Li, X. / Liu, Y. / Meijers, R. / Zhang, Y. / Wang, J.H. History Deposition Dec 22, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 4, 2018 Provider : repository / Type : Initial releaseRevision 1.1 Dec 4, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Oct 4, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id
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