登録情報 データベース : PDB / ID : 6bfs 構造の表示 ダウンロードとリンクタイトル The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies 要素Fab Heavy Chain Fab light Chain Granulocyte-macrophage colony-stimulating factor 詳細キーワード IMMUNE SYSTEM / Cytokine-Fab complex / Pulmonary Alveolar Proteinosis / receptor assembly / autoantibodies機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
granulocyte macrophage colony-stimulating factor receptor binding / histamine secretion / neutrophil differentiation / response to silicon dioxide / epithelial fluid transport / positive regulation of interleukin-23 production / regulation of circadian sleep/wake cycle, sleep / dendritic cell differentiation / response to fluid shear stress / positive regulation of macrophage derived foam cell differentiation ... granulocyte macrophage colony-stimulating factor receptor binding / histamine secretion / neutrophil differentiation / response to silicon dioxide / epithelial fluid transport / positive regulation of interleukin-23 production / regulation of circadian sleep/wake cycle, sleep / dendritic cell differentiation / response to fluid shear stress / positive regulation of macrophage derived foam cell differentiation / myeloid dendritic cell differentiation / granulocyte macrophage colony-stimulating factor receptor complex / granulocyte-macrophage colony-stimulating factor signaling pathway / myeloid cell differentiation / positive regulation of leukocyte proliferation / cellular response to granulocyte macrophage colony-stimulating factor stimulus / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / positive regulation of podosome assembly / Interleukin-10 signaling / cell surface receptor signaling pathway via JAK-STAT / monocyte differentiation / macrophage differentiation / Interleukin-3, Interleukin-5 and GM-CSF signaling / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / embryonic placenta development / Interleukin receptor SHC signaling / positive regulation of tyrosine phosphorylation of STAT protein / cytokine activity / growth factor activity / RAF/MAP kinase cascade / cellular response to lipopolysaccharide / cell population proliferation / positive regulation of cell migration / immune response / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of gene expression / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能 Granulocyte-macrophage colony-stimulating factor / Granulocyte-macrophage colony-stimulating factor / Granulocyte-macrophage colony-stimulating factor signature. / Granulocyte-macrophage colony-simulating factor (GM-CSF) / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Immunoglobulins / Up-down Bundle / Immunoglobulin-like ... Granulocyte-macrophage colony-stimulating factor / Granulocyte-macrophage colony-stimulating factor / Granulocyte-macrophage colony-stimulating factor signature. / Granulocyte-macrophage colony-simulating factor (GM-CSF) / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Immunoglobulins / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 Granulocyte-macrophage colony-stimulating factor 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Dhagat, U. / Hercus, T.R. / Broughton, S.E. / Nero, T.L. / Lopez, A.F. / Parker, M.W. 資金援助 オーストラリア, 1件 詳細 詳細を隠す組織 認可番号 国 National Health and Medical Research Council (NHMRC, Australia) オーストラリア
引用ジャーナル : MAbs / 年 : 2018タイトル : The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.著者 : Dhagat, U. / Hercus, T.R. / Broughton, S.E. / Nero, T.L. / Cheung Tung Shing, K.S. / Barry, E.F. / Thomson, C.A. / Bryson, S. / Pai, E.F. / McClure, B.J. / Schrader, J.W. / Lopez, A.F. / Parker, M.W. 履歴 登録 2017年10月26日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2018年9月12日 Provider : repository / タイプ : Initial release改定 1.1 2018年9月26日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID改定 1.2 2018年10月3日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2019年2月20日 Group : Author supporting evidence / Data collection / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.4 2020年1月8日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.5 2023年10月4日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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