登録情報 | データベース: PDB / ID: 5wb7 |
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タイトル | Crystal structure of the epidermal growth factor receptor extracellular region in complex with epiregulin |
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要素 | - Epidermal growth factor receptor
- Proepiregulin
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キーワード | SIGNALING PROTEIN / Receptor tyrosine kinase / growth factor / signaling / membrane protein |
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機能・相同性 | 機能・相同性情報
luteinizing hormone signaling pathway / ovarian cumulus expansion / ovulation / ERBB4-ERBB4 signaling pathway / negative regulation of smooth muscle cell differentiation / Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / ERBB2-ERBB4 signaling pathway / primary follicle stage / ERBB2-EGFR signaling pathway ...luteinizing hormone signaling pathway / ovarian cumulus expansion / ovulation / ERBB4-ERBB4 signaling pathway / negative regulation of smooth muscle cell differentiation / Inhibition of Signaling by Overexpressed EGFR / EGFR interacts with phospholipase C-gamma / ERBB2-ERBB4 signaling pathway / primary follicle stage / ERBB2-EGFR signaling pathway / ERBB2 Activates PTK6 Signaling / female meiotic nuclear division / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / PI3K events in ERBB4 signaling / Signaling by ERBB4 / ERBB2 Regulates Cell Motility / positive regulation of innate immune response / PI3K events in ERBB2 signaling / mRNA transcription / oocyte maturation / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / epidermal growth factor receptor binding / GAB1 signalosome / positive regulation of DNA replication / positive regulation of phosphorylation / positive regulation of cell division / Signaling by ERBB2 / keratinocyte proliferation / SHC1 events in ERBB4 signaling / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / anatomical structure morphogenesis / Complex I biogenesis / positive regulation of protein kinase activity / GRB2 events in ERBB2 signaling / SHC1 events in ERBB2 signaling / Respiratory electron transport / Nuclear signaling by ERBB4 / keratinocyte differentiation / positive regulation of mitotic nuclear division / positive regulation of smooth muscle cell proliferation / EGFR downregulation / Signaling by ERBB2 TMD/JMD mutants / : / clathrin-coated endocytic vesicle membrane / mitochondrial electron transport, NADH to ubiquinone / proton motive force-driven mitochondrial ATP synthesis / positive regulation of cytokine production / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / NADH dehydrogenase (ubiquinone) activity / animal organ morphogenesis / Downregulation of ERBB2 signaling / growth factor activity / wound healing / aerobic respiration / Constitutive Signaling by Aberrant PI3K in Cancer / response to peptide hormone / cytokine-mediated signaling pathway / positive regulation of fibroblast proliferation / positive regulation of interleukin-6 production / Cargo recognition for clathrin-mediated endocytosis / negative regulation of epithelial cell proliferation / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / cell-cell signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / angiogenesis / Extra-nuclear estrogen signaling / receptor ligand activity / electron transfer activity / mitochondrial inner membrane / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Furin-like cysteine rich region / Receptor L domain / Laminin / Laminin / NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / Zinc finger, CHCC-type / Zinc-finger domain / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. ...Furin-like cysteine rich region / Receptor L domain / Laminin / Laminin / NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial / Zinc finger, CHCC-type / Zinc-finger domain / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ribbon / Mainly Beta類似検索 - ドメイン・相同性 Proepiregulin / NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.941 Å |
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データ登録者 | Freed, D.M. / Bessman, N.J. / Ferguson, K.M. / Lemmon, M.A. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | R01-CA198164 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | U54-CA193417 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | F32-GM109688 | 米国 |
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引用 | ジャーナル: Cell / 年: 2017 タイトル: EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. 著者: Freed, D.M. / Bessman, N.J. / Kiyatkin, A. / Salazar-Cavazos, E. / Byrne, P.O. / Moore, J.O. / Valley, C.C. / Ferguson, K.M. / Leahy, D.J. / Lidke, D.S. / Lemmon, M.A. |
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履歴 | 登録 | 2017年6月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年10月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年10月25日 | Group: Database references / カテゴリ: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2017年11月1日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_validate_close_contact / pdbx_validate_symm_contact / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_close_contact.auth_asym_id_1 / _pdbx_validate_close_contact.auth_seq_id_1 / _pdbx_validate_symm_contact.auth_asym_id_2 / _pdbx_validate_symm_contact.auth_seq_id_2 / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag |
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