登録情報 | データベース: PDB / ID: 5vvv |
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タイトル | Structural Investigations of the Substrate Specificity of Human O-GlcNAcase |
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要素 | - Protein O-GlcNAcase
- a-crystallin B
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キーワード | HYDROLASE / OGA / Human O-GlcNAcase / a-crystalline B |
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機能・相同性 | 機能・相同性情報
microtubule polymerization or depolymerization / negative regulation of intracellular transport / hyalurononglucosaminidase activity / glycoprotein metabolic process / apoptotic process involved in morphogenesis / N-acetylglucosamine metabolic process / glycoprotein catabolic process / protein O-GlcNAcase / [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity / cardiac myofibril ...microtubule polymerization or depolymerization / negative regulation of intracellular transport / hyalurononglucosaminidase activity / glycoprotein metabolic process / apoptotic process involved in morphogenesis / N-acetylglucosamine metabolic process / glycoprotein catabolic process / protein O-GlcNAcase / [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity / cardiac myofibril / regulation of programmed cell death / tubulin complex assembly / protein deglycosylation / structural constituent of eye lens / protein O-linked glycosylation / negative regulation of amyloid fibril formation / M band / lens development in camera-type eye / muscle organ development / actin filament bundle / HSF1-dependent transactivation / negative regulation of reactive oxygen species metabolic process / negative regulation of protein-containing complex assembly / muscle contraction / stress-activated MAPK cascade / synaptic membrane / beta-N-acetylglucosaminidase activity / response to hydrogen peroxide / negative regulation of cell growth / cellular response to gamma radiation / Z disc / unfolded protein binding / protein folding / response to estradiol / amyloid-beta binding / protein refolding / response to heat / microtubule binding / perikaryon / dendritic spine / lysosome / response to hypoxia / protein stabilization / axon / negative regulation of gene expression / negative regulation of DNA-templated transcription / protein-containing complex binding / negative regulation of apoptotic process / structural molecule activity / cell surface / protein homodimerization activity / protein-containing complex / mitochondrion / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / metal ion binding / cytosol / cytoplasm類似検索 - 分子機能 Alpha-crystallin B chain, ACD domain / Alpha-crystallin, N-terminal / Alpha crystallin A chain, N terminal / Alpha crystallin/Small heat shock protein, animal type / : / Glycosyl hydrolases family 84 (GH84) domain profile. / Beta-N-acetylglucosaminidase / beta-N-acetylglucosaminidase / Hsp20/alpha crystallin family / Small heat shock protein (sHSP) domain profile. ...Alpha-crystallin B chain, ACD domain / Alpha-crystallin, N-terminal / Alpha crystallin A chain, N terminal / Alpha crystallin/Small heat shock protein, animal type / : / Glycosyl hydrolases family 84 (GH84) domain profile. / Beta-N-acetylglucosaminidase / beta-N-acetylglucosaminidase / Hsp20/alpha crystallin family / Small heat shock protein (sHSP) domain profile. / Alpha crystallin/Hsp20 domain / HSP20-like chaperone / Acyl-CoA N-acyltransferase / Glycosidases / Glycoside hydrolase superfamily / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Protein O-GlcNAcase / Alpha-crystallin B chain類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Li, B. / Jiang, J. / Li, H. / Hu, C.-W. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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University of Wisconsin-Madison | | 米国 |
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引用 | ジャーナル: Nat Commun / 年: 2017 タイトル: Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. 著者: Li, B. / Li, H. / Hu, C.W. / Jiang, J. |
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履歴 | 登録 | 2017年5月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2017年9月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年10月4日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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改定 1.2 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.3 | 2023年10月4日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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