登録情報 データベース : PDB / ID : 5uc6 構造の表示 ダウンロードとリンクタイトル Structural insights into IL-1 alpha recognition by a naphthyl-modified aptamer that mimics IL-1RI Domain III 要素DNA (5'-D(*CP*G)-R(P*(85Y))-D(P*GP*AP*G)-R(P*(85Y)P*(85Y))-D(P*A)-R(P*(85Y))-D(P*GP*GP*G)-R(P*(85Y)P*(85Y))-D(P*AP*GP*AP*G)-R(P*(85Y))-D(P*CP*GP*(ATD))-3')Interleukin-1 alpha 詳細キーワード IMMUNE SYSTEM/DNA / SOMAmer / IMMUNE SYSTEM-DNA complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of establishment of Sertoli cell barrier / positive regulation of neutrophil migration / positive regulation of steroid biosynthetic process / connective tissue replacement involved in inflammatory response wound healing / response to L-ascorbic acid / response to ozone / positive regulation of stress-activated MAPK cascade / positive regulation of immature T cell proliferation in thymus / positive regulation of prostaglandin secretion / interleukin-1 receptor binding ... negative regulation of establishment of Sertoli cell barrier / positive regulation of neutrophil migration / positive regulation of steroid biosynthetic process / connective tissue replacement involved in inflammatory response wound healing / response to L-ascorbic acid / response to ozone / positive regulation of stress-activated MAPK cascade / positive regulation of immature T cell proliferation in thymus / positive regulation of prostaglandin secretion / interleukin-1 receptor binding / Interleukin-1 processing / fever generation / intracellular sodium ion homeostasis / response to copper ion / : / keratinization / Interleukin-10 signaling / positive regulation of cell division / ectopic germ cell programmed cell death / Pyroptosis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of vascular endothelial growth factor production / Purinergic signaling in leishmaniasis infection / extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of interleukin-2 production / positive regulation of mitotic nuclear division / response to gamma radiation / positive regulation of cytokine production / cytokine activity / regulation of actin cytoskeleton organization / positive regulation of protein secretion / positive regulation of JNK cascade / cytokine-mediated signaling pathway / positive regulation of interleukin-6 production / Interleukin-1 signaling / positive regulation of angiogenesis / positive regulation of tumor necrosis factor production / heart development / cellular response to heat / Senescence-Associated Secretory Phenotype (SASP) / spermatogenesis / cellular response to lipopolysaccharide / Interleukin-4 and Interleukin-13 signaling / positive regulation of canonical NF-kappaB signal transduction / positive regulation of ERK1 and ERK2 cascade / response to hypoxia / inflammatory response / immune response / copper ion binding / negative regulation of cell population proliferation / positive regulation of gene expression / apoptotic process / cell surface / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / nucleus / cytosol 類似検索 - 分子機能 Interleukin-1 alpha / Interleukin-1 propeptide / Interleukin-1 propeptide / Interleukin-1 conserved site / Interleukin-1 signature. / Interleukin-1 homologues / Interleukin-1 family / Interleukin-1 / 18 / Cytokine IL1/FGF / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 ... Interleukin-1 alpha / Interleukin-1 propeptide / Interleukin-1 propeptide / Interleukin-1 conserved site / Interleukin-1 signature. / Interleukin-1 homologues / Interleukin-1 family / Interleukin-1 / 18 / Cytokine IL1/FGF / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / Mainly Beta 類似検索 - ドメイン・相同性 PHOSPHATE ION / DNA / DNA (> 10) / Interleukin-1 alpha 類似検索 - 構成要素生物種 Homo sapiens (ヒト)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.1 Å 詳細データ登録者 Ren, X. / Pyle, A. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 Howard Hughes Medical Institute (HHMI) 米国
引用ジャーナル : Nat Commun / 年 : 2017タイトル : Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling.著者 : Ren, X. / Gelinas, A.D. / von Carlowitz, I. / Janjic, N. / Pyle, A.M. 履歴 登録 2016年12月21日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2017年10月11日 Provider : repository / タイプ : Initial release改定 1.1 2017年10月18日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 2.0 2017年11月15日 Group : Atomic model / Derived calculations ... Atomic model / Derived calculations / Non-polymer description / Structure summary カテゴリ : atom_site / entity ... atom_site / entity / struct_conn / struct_site Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.id / _chem_comp.name / _entity.formula_weight / _entity.pdbx_description / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_label_comp_id / _struct_site.details / _struct_site.pdbx_auth_comp_id 改定 3.0 2018年8月22日 Group : Atomic model / Data collection / Derived calculationsカテゴリ : atom_site / pdbx_validate_rmsd_angle / struct_connItem : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.label_atom_id / _struct_conn.pdbx_leaving_atom_flag 改定 3.1 2019年11月20日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 3.2 2023年10月4日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
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