Entry | Database: PDB / ID: 5u6e |
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Title | Crystal structure of clade A/E HIV-1 gp120 core in complex with NBD-14010 |
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Components | clade A/E 93TH057 HIV-1 gp120 core |
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Keywords | VIRAL PROTEIN / HIV-1 / NBD-14010 / virus entry antagonist / small molecule |
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Function / homology | Function and homology information
HIV Envelope Protein Gp120; Chain G / Human immunodeficiency virus 1, Gp160, envelope glycoprotein / Gp120 core superfamily / Envelope glycoprotein GP120 / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Beta Complex / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Human immunodeficiency virus 1 |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.095 Å |
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Authors | Kwon, Y.D. / Debnath, A.K. / Kwong, P.D. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | W-31-109-Eng-38 | United States |
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Citation | Journal: J. Med. Chem. / Year: 2017 Title: Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120. Authors: Curreli, F. / Kwon, Y.D. / Belov, D.S. / Ramesh, R.R. / Kurkin, A.V. / Altieri, A. / Kwong, P.D. / Debnath, A.K. |
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History | Deposition | Dec 7, 2016 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 22, 2017 | Provider: repository / Type: Initial release |
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Revision 1.1 | Apr 26, 2017 | Group: Database references |
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Revision 1.2 | Aug 23, 2017 | Group: Data collection / Category: diffrn_detector / Item: _diffrn_detector.type |
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Revision 1.3 | Dec 4, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.4 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.5 | Oct 4, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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