登録情報 データベース : PDB / ID : 5u4x 構造の表示 ダウンロードとリンクタイトル Coactivator-associated arginine methyltransferase 1 with TP-064 要素Histone-arginine methyltransferase CARM1 詳細 キーワード TRANSFERASE / CARM1 / methyltransferase / TP-064 / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / histone arginine N-methyltransferase activity / protein methyltransferase activity / regulation of intracellular estrogen receptor signaling pathway / replication fork reversal / protein-arginine N-methyltransferase activity ... histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / histone arginine N-methyltransferase activity / protein methyltransferase activity / regulation of intracellular estrogen receptor signaling pathway / replication fork reversal / protein-arginine N-methyltransferase activity / positive regulation of epithelial cell apoptotic process / positive regulation of transcription by RNA polymerase I / histone methyltransferase activity / nuclear replication fork / positive regulation of fat cell differentiation / response to cAMP / RORA activates gene expression / Regulation of lipid metabolism by PPARalpha / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) / nuclear receptor coactivator activity / lysine-acetylated histone binding / Heme signaling / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / Cytoprotection by HMOX1 / beta-catenin binding / RMTs methylate histone arginines / Transcriptional regulation of white adipocyte differentiation / Circadian Clock / DNA-binding transcription factor binding / Estrogen-dependent gene expression / methylation / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / positive regulation of cell population proliferation / regulation of DNA-templated transcription / nucleoplasm / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Arginine methyltransferase oligomerization subdomain / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich ... Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Arginine methyltransferase oligomerization subdomain / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Chem-7VM / S-ADENOSYL-L-HOMOCYSTEINE / Histone-arginine methyltransferase CARM1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.88 Å 詳細データ登録者 DONG, A. / ZENG, H. / Saikatendu, K.S. / STONE, H. / WALKER, J.R. / Seitova, A. / Hutchinson, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. ...DONG, A. / ZENG, H. / Saikatendu, K.S. / STONE, H. / WALKER, J.R. / Seitova, A. / Hutchinson, A. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / BROWN, P.J. / WU, H. / Structural Genomics Consortium (SGC) 引用ジャーナル : Oncotarget / 年 : 2018タイトル : TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.著者: Nakayama, K. / Szewczyk, M.M. / Dela Sena, C. / Wu, H. / Dong, A. / Zeng, H. / Li, F. / de Freitas, R.F. / Eram, M.S. / Schapira, M. / Baba, Y. / Kunitomo, M. / Cary, D.R. / Tawada, M. / ... 著者 : Nakayama, K. / Szewczyk, M.M. / Dela Sena, C. / Wu, H. / Dong, A. / Zeng, H. / Li, F. / de Freitas, R.F. / Eram, M.S. / Schapira, M. / Baba, Y. / Kunitomo, M. / Cary, D.R. / Tawada, M. / Ohashi, A. / Imaeda, Y. / Saikatendu, K.S. / Grimshaw, C.E. / Vedadi, M. / Arrowsmith, C.H. / Barsyte-Lovejoy, D. / Kiba, A. / Tomita, D. / Brown, P.J. 履歴 登録 2016年12月6日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年12月21日 Provider : repository / タイプ : Initial release改定 1.1 2018年1月24日 Group : Structure summary / カテゴリ : audit_author / struct / Item : _struct.title改定 1.2 2018年5月23日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.3 2023年10月4日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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