Entry Database : PDB / ID : 5tz1 Structure visualization Downloads & linksTitle Crystal structure of sterol 14-alpha demethylase (CYP51) from Candida albicans in complex with the tetrazole-based antifungal drug candidate VT1161 (VT1) ComponentsSterol 14-alpha demethylase Details Keywords OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / CYP51 / cytochrome P450 / heme / oxidoreductase / monooxygenase / sterol biosynthesis / eukaryotic membranes / cytochrome P450 fold / endoplasmic reticulum membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
cell growth mode switching, budding to filamentous / membrane raft polarization / sterol 14alpha-demethylase / sterol 14-demethylase activity / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / perinuclear endoplasmic reticulum / cortical endoplasmic reticulum / endosome organization / bile acid biosynthetic process ... cell growth mode switching, budding to filamentous / membrane raft polarization / sterol 14alpha-demethylase / sterol 14-demethylase activity / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / perinuclear endoplasmic reticulum / cortical endoplasmic reticulum / endosome organization / bile acid biosynthetic process / ergosterol biosynthetic process / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen / monooxygenase activity / methyltransferase activity / cholesterol homeostasis / lipid metabolic process / methylation / oxidoreductase activity / iron ion binding / heme binding / endoplasmic reticulum membrane / membrane / plasma membrane Similarity search - Function Cytochrome P450, E-class, group IV / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 Similarity search - Domain/homologyBiological species Candida albicans (yeast)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Hargrove, T. / Wawrzak, Z. / Lepesheva, G. CitationJournal : J. Biol. Chem. / Year : 2017Title : Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.Authors : Hargrove, T.Y. / Friggeri, L. / Wawrzak, Z. / Qi, A. / Hoekstra, W.J. / Schotzinger, R.J. / York, J.D. / Guengerich, F.P. / Lepesheva, G.I. History Deposition Nov 21, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 15, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Mar 22, 2017 Group : Database referencesRevision 1.2 May 3, 2017 Group : Database referencesRevision 1.3 Nov 22, 2017 Group : Refinement description / Category : software / Item : _software.classificationRevision 1.4 Oct 4, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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