登録情報 データベース : PDB / ID : 5mdi 構造の表示 ダウンロードとリンクタイトル Crystal structure of TDP-43 N-terminal domain at 2.1 A resolution 要素TAR DNA-binding protein 43 詳細 キーワード RNA BINDING PROTEIN / RNA binding proteins / Dynamic polymerization / ALS / protein aggregation機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
nuclear inner membrane organization / interchromatin granule / perichromatin fibrils / 3'-UTR-mediated mRNA destabilization / 3'-UTR-mediated mRNA stabilization / intracellular membraneless organelle / negative regulation of protein phosphorylation / host-mediated suppression of viral transcription / pre-mRNA intronic binding / RNA splicing ... nuclear inner membrane organization / interchromatin granule / perichromatin fibrils / 3'-UTR-mediated mRNA destabilization / 3'-UTR-mediated mRNA stabilization / intracellular membraneless organelle / negative regulation of protein phosphorylation / host-mediated suppression of viral transcription / pre-mRNA intronic binding / RNA splicing / response to endoplasmic reticulum stress / mRNA 3'-UTR binding / molecular condensate scaffold activity / regulation of circadian rhythm / regulation of protein stability / positive regulation of insulin secretion / positive regulation of protein import into nucleus / mRNA processing / cytoplasmic stress granule / rhythmic process / regulation of gene expression / double-stranded DNA binding / regulation of apoptotic process / amyloid fibril formation / regulation of cell cycle / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / lipid binding / chromatin / mitochondrion / DNA binding / RNA binding / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 TAR DNA-binding protein 43, N-terminal / : / TAR DNA-binding protein 43, N-terminal domain / TAR DNA-binding protein 43, C-terminal / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily 類似検索 - ドメイン・相同性 ACETATE ION / TAR DNA binding protein / TAR DNA-binding protein 43 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 単波長異常分散 / 解像度 : 2.1 Å 詳細データ登録者 Afroz, T. / Hock, E.-M. / Ernst, P. / Foglieni, C. / Jambeau, M. / Gilhespy, L. / Laferriere, F. / Maniecka, Z. / Plueckthun, A. / Mittl, P. ...Afroz, T. / Hock, E.-M. / Ernst, P. / Foglieni, C. / Jambeau, M. / Gilhespy, L. / Laferriere, F. / Maniecka, Z. / Plueckthun, A. / Mittl, P. / Paganetti, P. / Allain, F.H.T. / Polymenidou, M. 引用ジャーナル : Nat Commun / 年 : 2017タイトル : Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.著者 : Afroz, T. / Hock, E.M. / Ernst, P. / Foglieni, C. / Jambeau, M. / Gilhespy, L.A.B. / Laferriere, F. / Maniecka, Z. / Pluckthun, A. / Mittl, P. / Paganetti, P. / Allain, F.H.T. / Polymenidou, M. 履歴 登録 2016年11月11日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2017年7月5日 Provider : repository / タイプ : Initial release改定 1.1 2017年7月12日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_volume ... _citation.country / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name 改定 1.2 2024年11月13日 Group : Data collection / Database references / Structure summaryカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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