登録情報 データベース : PDB / ID : 5lqc 構造の表示 ダウンロードとリンクタイトル Crystal Structure of COMT in complex with N-[(E)-3-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]prop-2-enyl]-5-(4-fluorophenyl)-2,3-dihydroxybenzamide 要素Catechol O-methyltransferase 詳細 キーワード TRANSFERASE / METHYLTRANSFERASE / NEUROTRANSMITTER DEGRADATION機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of homocysteine metabolic process / Enzymatic degradation of dopamine by COMT / Enzymatic degradation of Dopamine by monoamine oxidase / Methylation / norepinephrine secretion / response to dopamine / mastication / catecholamine catabolic process / catechol O-methyltransferase activity / S-adenosylhomocysteine metabolic process ... positive regulation of homocysteine metabolic process / Enzymatic degradation of dopamine by COMT / Enzymatic degradation of Dopamine by monoamine oxidase / Methylation / norepinephrine secretion / response to dopamine / mastication / catecholamine catabolic process / catechol O-methyltransferase activity / S-adenosylhomocysteine metabolic process / catechol O-methyltransferase / developmental process / renal sodium excretion / renal filtration / S-adenosylmethionine metabolic process / renin secretion into blood stream / dopamine secretion / catecholamine metabolic process / renal albumin absorption / artery development / habituation / cerebellar cortex morphogenesis / dopamine catabolic process / glomerulus development / response to salt / norepinephrine metabolic process / short-term memory / fear response / response to angiotensin / synaptic transmission, dopaminergic / cellular response to phosphate starvation / cellular response to cocaine / estrogen metabolic process / cholesterol efflux / response to food / prostaglandin metabolic process / negative regulation of dopamine metabolic process / response to pain / response to corticosterone / response to temperature stimulus / glycogen metabolic process / response to stress / startle response / exploration behavior / dopamine metabolic process / detection of temperature stimulus involved in sensory perception of pain / : / behavioral fear response / multicellular organismal response to stress / response to cytokine / response to amphetamine / female pregnancy / learning / negative regulation of smooth muscle cell proliferation / kidney development / visual learning / regulation of blood pressure / response to toxic substance / response to wounding / multicellular organism growth / response to estrogen / cognition / memory / cell body / response to lipopolysaccharide / methylation / vesicle / dendritic spine / response to oxidative stress / gene expression / postsynaptic membrane / response to hypoxia / learning or memory / postsynapse / response to xenobiotic stimulus / axon / dendrite / glutamatergic synapse / magnesium ion binding / membrane / cytosol 類似検索 - 分子機能 Catechol O-methyltransferase, eukaryotic / Class I-like SAM-dependent O-methyltransferase / O-methyltransferase / SAM-dependent O-methyltransferase class I-type profile. / Vaccinia Virus protein VP39 / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.903 Å 詳細データ登録者 Ehler, A. / Ellermann, M. / Lerner, C. / Rudolph, M.G. 引用ジャーナル : To be published タイトル : no title yet著者 : Ellermann, M. / Lerner, C. / Rudolph, M.G. 履歴 登録 2016年8月16日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2016年8月31日 Provider : repository / タイプ : Initial release改定 1.1 2024年5月1日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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