Entry Database : PDB / ID : 5lof Structure visualization Downloads & linksTitle Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1 ComponentsMaltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1 Details Keywords APOPTOSIS/INHIBITOR / APOPTOSIS-INHIBITOR COMPLEX / MCL-1 / S S63845 / MBPFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / cell fate determination / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH3 domain binding / carbohydrate transmembrane transporter activity / negative regulation of anoikis / maltose binding ... positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cellular homeostasis / cell fate determination / channel activity / mitochondrial fusion / Bcl-2 family protein complex / BH3 domain binding / carbohydrate transmembrane transporter activity / negative regulation of anoikis / maltose binding / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / maltose transport / maltodextrin transmembrane transport / protein transmembrane transporter activity / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / response to cytokine / intrinsic apoptotic signaling pathway in response to DNA damage / Signaling by ALK fusions and activated point mutants / outer membrane-bounded periplasmic space / regulation of apoptotic process / Interleukin-4 and Interleukin-13 signaling / mitochondrial outer membrane / positive regulation of apoptotic process / protein heterodimerization activity / DNA damage response / negative regulation of apoptotic process / protein homodimerization activity / mitochondrion / nucleoplasm / membrane / nucleus / cytoplasm / cytosol Similarity search - Function Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 ... Apoptosis regulator, Mcl-1 / Apoptosis regulator, Bcl-2, BH3 motif, conserved site / Apoptosis regulator, Bcl-2 family BH3 motif signature. / Apoptosis regulator, Bcl-2, BH1 motif, conserved site / Apoptosis regulator, Bcl-2 family BH1 motif signature. / Apoptosis regulator, Bcl-2, BH2 motif, conserved site / Apoptosis regulator, Bcl-2 family BH2 motif signature. / BCL (B-Cell lymphoma); contains BH1, BH2 regions / Bcl-2 family / Bcl-2, Bcl-2 homology region 1-3 / Bcl2-like / Apoptosis regulator proteins, Bcl-2 family / BCL2-like apoptosis inhibitors family profile. / Bcl-2-like superfamily / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein Similarity search - Domain/homology alpha-maltose / Chem-70R / Maltose/maltodextrin-binding periplasmic protein / Induced myeloid leukemia cell differentiation protein Mcl-1 Similarity search - ComponentBiological species Escherichia coli O157:H7 (bacteria)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Dokurno, P. / Kotschy, A. / Szlavik, Z. / Murray, J. / Davidson, J. / Csekei, M. / Paczal, A. / Szabo, Z. / Sipos, S. / Radics, G. ...Dokurno, P. / Kotschy, A. / Szlavik, Z. / Murray, J. / Davidson, J. / Csekei, M. / Paczal, A. / Szabo, Z. / Sipos, S. / Radics, G. / Proszenyak, A. / Balint, B. / Ondi, L. / Blasko, G. / Robertson, A. / Surgenor, A. / Chen, I. / Matassova, N. / Smith, J. / Pedder, C. / Graham, C. / Geneste, O. CitationJournal : Nature / Year : 2016Title : The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.Authors: Kotschy, A. / Szlavik, Z. / Murray, J. / Davidson, J. / Maragno, A.L. / Le Toumelin-Braizat, G. / Chanrion, M. / Kelly, G.L. / Gong, J.N. / Moujalled, D.M. / Bruno, A. / Csekei, M. / Paczal, ... Authors : Kotschy, A. / Szlavik, Z. / Murray, J. / Davidson, J. / Maragno, A.L. / Le Toumelin-Braizat, G. / Chanrion, M. / Kelly, G.L. / Gong, J.N. / Moujalled, D.M. / Bruno, A. / Csekei, M. / Paczal, A. / Szabo, Z.B. / Sipos, S. / Radics, G. / Proszenyak, A. / Balint, B. / Ondi, L. / Blasko, G. / Robertson, A. / Surgenor, A. / Dokurno, P. / Chen, I. / Matassova, N. / Smith, J. / Pedder, C. / Graham, C. / Studeny, A. / Lysiak-Auvity, G. / Girard, A.M. / Grave, F. / Segal, D. / Riffkin, C.D. / Pomilio, G. / Galbraith, L.C. / Aubrey, B.J. / Brennan, M.S. / Herold, M.J. / Chang, C. / Guasconi, G. / Cauquil, N. / Melchiore, F. / Guigal-Stephan, N. / Lockhart, B. / Colland, F. / Hickman, J.A. / Roberts, A.W. / Huang, D.C. / Wei, A.H. / Strasser, A. / Lessene, G. / Geneste, O. History Deposition Aug 9, 2016 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 26, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Nov 2, 2016 Group : Database referencesRevision 1.2 Nov 9, 2016 Group : Database referencesRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Derived calculations / Non-polymer description / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.src_method / _entity.type Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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