Entry Database : PDB / ID : 5kh2 Structure visualization Downloads & linksTitle Crystal Structure of Steptococcus pneumoniae Undecaprenyl pyrophosphate Synthase (UPPS) ComponentsIsoprenyl transferase Details Keywords TRANSFERASE / UPPS / native / bacterial / undecaprenyl S. pneumoniaeFunction / homology Function and homology informationFunction Domain/homology Component
Z-farnesyl diphosphate synthase activity / polyprenyltransferase activity / di-trans,poly-cis-undecaprenyl-diphosphate synthase activity / polyprenol biosynthetic process / Transferases; Transferring alkyl or aryl groups, other than methyl groups / manganese ion binding / magnesium ion binding / plasma membrane / cytosol Similarity search - Function Undecaprenyl pyrophosphate synthetase / Decaprenyl diphosphate synthase-like / Di-trans-poly-cis-decaprenylcistransferase-like, conserved site / Undecaprenyl pyrophosphate synthase family signature. / Decaprenyl diphosphate synthase-like / Putative undecaprenyl diphosphate synthase / Decaprenyl diphosphate synthase-like superfamily / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Streptococcus pneumoniae serotype 4 (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.3 Å DetailsAuthors Concha, N.O. CitationJournal : J.Med.Chem. / Year : 2016Title : Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase.Authors: Concha, N. / Huang, J. / Bai, X. / Benowitz, A. / Brady, P. / Grady, L.C. / Kryn, L.H. / Holmes, D. / Ingraham, K. / Jin, Q. / Pothier Kaushansky, L. / McCloskey, L. / Messer, J.A. / ... Authors : Concha, N. / Huang, J. / Bai, X. / Benowitz, A. / Brady, P. / Grady, L.C. / Kryn, L.H. / Holmes, D. / Ingraham, K. / Jin, Q. / Pothier Kaushansky, L. / McCloskey, L. / Messer, J.A. / O'Keefe, H. / Patel, A. / Satz, A.L. / Sinnamon, R.H. / Schneck, J. / Skinner, S.R. / Summerfield, J. / Taylor, A. / Taylor, J.D. / Evindar, G. / Stavenger, R.A. History Deposition Jun 14, 2016 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 20, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Aug 24, 2016 Group : Database referencesRevision 1.2 Mar 13, 2019 Group : Data collection / Database references / Derived calculationsCategory : citation / diffrn ... citation / diffrn / diffrn_radiation / diffrn_source / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _diffrn.pdbx_serial_crystal_experiment ... _citation.journal_id_CSD / _diffrn.pdbx_serial_crystal_experiment / _diffrn_radiation.pdbx_monochromatic_or_laue_m_l / _diffrn_source.pdbx_wavelength_list / _pdbx_struct_oper_list.symmetry_operation Revision 1.3 Mar 6, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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