登録情報 | データベース: PDB / ID: 5kdh |
---|
タイトル | CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIHYDROPYRIDOPYRIMIDINE SCAFFOLD INHIBITOR |
---|
要素 | Bromodomain-containing protein 4 |
---|
キーワード | TRANSCRIPTION/INHIBITOR / BROMODOMAIN / CAP / HUNK1 / MCAP / PROTEIN BINDING-INHIBITOR COMPLEX / MITOTIC CHROMOSOME ASSOCIATED PROTEIN / CELL CYCLE / INHIBITOR / TRANSCRIPTION-INHIBITOR COMPLEX |
---|
機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.5 Å |
---|
データ登録者 | Zhu, J.-Y. / Schonbrunn, E. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | 5 U01 HD076542 (GIG) | 米国 | National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | HHSN275201300017C (GIG) | 米国 |
|
---|
引用 | ジャーナル: J. Med. Chem. / 年: 2017 タイトル: BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. 著者: Ayoub, A.M. / Hawk, L.M.L. / Herzig, R.J. / Jiang, J. / Wisniewski, A.J. / Gee, C.T. / Zhao, P. / Zhu, J.Y. / Berndt, N. / Offei-Addo, N.K. / Scott, T.G. / Qi, J. / Bradner, J.E. / Ward, T.R. ...著者: Ayoub, A.M. / Hawk, L.M.L. / Herzig, R.J. / Jiang, J. / Wisniewski, A.J. / Gee, C.T. / Zhao, P. / Zhu, J.Y. / Berndt, N. / Offei-Addo, N.K. / Scott, T.G. / Qi, J. / Bradner, J.E. / Ward, T.R. / Schonbrunn, E. / Georg, G.I. / Pomerantz, W.C.K. |
---|
履歴 | 登録 | 2016年6月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2017年8月2日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2017年9月13日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support |
---|
改定 1.2 | 2019年12月11日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
改定 1.3 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|