登録情報 データベース : PDB / ID : 5hbj 構造の表示 ダウンロードとリンクタイトル CDK8-CYCC IN COMPLEX WITH 8-[2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one 要素Cyclin-C Cyclin-dependent kinase 8 詳細キーワード TRANSFERASE / CDK8 KINASE / CYCLIN C機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
CKM complex / G0 to G1 transition / negative regulation of triglyceride metabolic process / mediator complex / Generic Transcription Pathway / [RNA-polymerase]-subunit kinase / cyclin-dependent protein serine/threonine kinase regulator activity / RSV-host interactions / negative regulation of Notch signaling pathway / cyclin-dependent kinase ... CKM complex / G0 to G1 transition / negative regulation of triglyceride metabolic process / mediator complex / Generic Transcription Pathway / [RNA-polymerase]-subunit kinase / cyclin-dependent protein serine/threonine kinase regulator activity / RSV-host interactions / negative regulation of Notch signaling pathway / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / cyclin-dependent protein kinase holoenzyme complex / ubiquitin ligase complex / RNA polymerase II CTD heptapeptide repeat kinase activity / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / PPARA activates gene expression / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / Transcriptional regulation of white adipocyte differentiation / ubiquitin protein ligase activity / protein kinase activity / protein ubiquitination / protein serine kinase activity / protein serine/threonine kinase activity / nucleolus / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / ATP binding / identical protein binding / nucleus 類似検索 - 分子機能 Cyclin, C-terminal domain 2 / Cyclin C-terminal domain / Cyclin/Cyclin-like subunit Ssn8 / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma / Cyclin-like superfamily ... Cyclin, C-terminal domain 2 / Cyclin C-terminal domain / Cyclin/Cyclin-like subunit Ssn8 / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma / Cyclin-like superfamily / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-5Y8 / FORMIC ACID / Cyclin-C / Cyclin-dependent kinase 8 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3 Å 詳細データ登録者 Musil, D. / Blagg, J. / Mallinger, A. 引用ジャーナル : J.Med.Chem. / 年 : 2016タイトル : Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.著者: Mallinger, A. / Schiemann, K. / Rink, C. / Stieber, F. / Calderini, M. / Crumpler, S. / Stubbs, M. / Adeniji-Popoola, O. / Poeschke, O. / Busch, M. / Czodrowski, P. / Musil, D. / Schwarz, D. ... 著者 : Mallinger, A. / Schiemann, K. / Rink, C. / Stieber, F. / Calderini, M. / Crumpler, S. / Stubbs, M. / Adeniji-Popoola, O. / Poeschke, O. / Busch, M. / Czodrowski, P. / Musil, D. / Schwarz, D. / Ortiz-Ruiz, M.J. / Schneider, R. / Thai, C. / Valenti, M. / de Haven Brandon, A. / Burke, R. / Workman, P. / Dale, T. / Wienke, D. / Clarke, P.A. / Esdar, C. / Raynaud, F.I. / Eccles, S.A. / Rohdich, F. / Blagg, J. 履歴 登録 2015年12月31日 登録サイト : RCSB / 処理サイト : PDBE改定 1.0 2016年2月3日 Provider : repository / タイプ : Initial release改定 1.1 2016年2月24日 Group : Database references改定 1.2 2024年5月8日 Group : Data collection / Database referencesカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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