登録情報 データベース : PDB / ID : 5fw5 構造の表示 ダウンロードとリンクタイトル Crystal structure of human G3BP1 in complex with Semliki Forest Virus nsP3-25 comprising two FGDF motives 要素NON-STRUCTURAL PROTEIN 3 RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN 1 詳細キーワード HYDROLASE / TRANSFERASE / NONSTRUCTURAL PROTEIN 3 (NSP3) / RAS-GTPASE ACTIVATING PROTEIN SH3 DOMAIN BINDING PROTEIN G3BP1 / RASPUTIN / STRESS GRANULE ASSOCIATED機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
DNA/RNA helicase activity / positive regulation of stress granule assembly / host cell filopodium / ADP-ribose 1''-phosphate phosphatase / mRNA methyltransferase activity / mRNA 5'-triphosphate monophosphatase activity / mRNA 5'-phosphatase / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity ... DNA/RNA helicase activity / positive regulation of stress granule assembly / host cell filopodium / ADP-ribose 1''-phosphate phosphatase / mRNA methyltransferase activity / mRNA 5'-triphosphate monophosphatase activity / mRNA 5'-phosphatase / polynucleotide 5'-phosphatase activity / polynucleotide adenylyltransferase / poly(A) RNA polymerase activity / symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity / ribosomal small subunit binding / 7-methylguanosine mRNA capping / positive regulation of type I interferon production / stress granule assembly / cysteine-type peptidase activity / DNA helicase activity / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / 転移酵素; 一炭素原子の基を移すもの; メチル基を移すもの / molecular condensate scaffold activity / host cell cytoplasmic vesicle membrane / negative regulation of canonical Wnt signaling pathway / cytoplasmic stress granule / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / nucleoside-triphosphate phosphatase / perikaryon / endonuclease activity / defense response to virus / DNA helicase / Ras protein signal transduction / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / RNA helicase activity / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / RNA helicase / ribonucleoprotein complex / RNA-directed RNA polymerase / viral RNA genome replication / RNA-dependent RNA polymerase activity / innate immune response / focal adhesion / virus-mediated perturbation of host defense response / DNA-templated transcription / mRNA binding / host cell nucleus / GTP binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / ATP hydrolysis activity / proteolysis / DNA binding / RNA binding / ATP binding / membrane / nucleus / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 G3BP1, RNA recognition motif / Ras GTPase-activating protein-binding protein / Nuclear transport factor 2, eukaryote / Nuclear transport factor 2 domain profile. / Nuclear transport factor 2 domain / Nuclear transport factor 2 (NTF2) domain / : / : / : / Non-structural protein 3, zinc-binding domain ... G3BP1, RNA recognition motif / Ras GTPase-activating protein-binding protein / Nuclear transport factor 2, eukaryote / Nuclear transport factor 2 domain profile. / Nuclear transport factor 2 domain / Nuclear transport factor 2 (NTF2) domain / : / : / : / Non-structural protein 3, zinc-binding domain / Tomato mosaic virus helicase, N-terminal domain / Alphavirus nsP2 protease domain superfamily / Alphavirus nsp2 protease (nsp2pro) domain / Peptidase family C9 / Alphavirus nsp2 protease (nsp2pro) domain profile. / Viral methyltransferase / Alphavirus-like methyltransferase (MT) domain / Alphavirus-like methyltransferase (MT) domain profile. / Tymovirus, RNA-dependent RNA polymerase / RNA dependent RNA polymerase / Viral (Superfamily 1) RNA helicase / Nuclear Transport Factor 2; Chain: A, - #50 / NTF2-like domain superfamily / Nuclear Transport Factor 2; Chain: A, / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / (+) RNA virus helicase core domain / (+)RNA virus helicase core domain profile. / Non-structural protein 3, X-domain-like / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like / Nucleotide-binding alpha-beta plait domain superfamily / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Roll / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase / Alpha Beta 類似検索 - ドメイン・相同性 ACETATE ION / : / Polyprotein P1234 / Ras GTPase-activating protein-binding protein 1 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト) SEMLIKI FOREST VIRUS (セムリキ森林ウイルス)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.92 Å 詳細データ登録者 Schulte, T. / Liu, L. / Panas, M.D. / Thaa, B. / Goette, B. / Achour, A. / McInerney, G.M. 引用ジャーナル : Open Biol / 年 : 2016タイトル : Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication.著者 : Schulte, T. / Liu, L. / Panas, M.D. / Thaa, B. / Dickson, N. / Gotte, B. / Achour, A. / McInerney, G.M. 履歴 登録 2016年2月12日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2016年7月20日 Provider : repository / タイプ : Initial release改定 1.1 2016年12月28日 Group : Derived calculations / Other改定 1.2 2017年3月22日 Group : Database references / Source and taxonomy改定 1.3 2024年1月10日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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