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- PDB-5dxh: p110alpha/p85alpha with compound 5 -

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Open data


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Basic information

Entry
Database: PDB / ID: 5dxh
Titlep110alpha/p85alpha with compound 5
Components
  • Phosphatidylinositol 3-kinase regulatory subunit alpha
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
KeywordsTransferase/Transferase Inhibitor / lipid kinase / Transferase-Transferase Inhibitor complex
Function / homology
Function and homology information


Signaling by ALK / MET activates PI3K/AKT signaling / RHOC GTPase cycle / CDC42 GTPase cycle / RAC1 GTPase cycle / RAC2 GTPase cycle / RHOD GTPase cycle / RHOJ GTPase cycle / RAC3 GTPase cycle / RHOF GTPase cycle ...Signaling by ALK / MET activates PI3K/AKT signaling / RHOC GTPase cycle / CDC42 GTPase cycle / RAC1 GTPase cycle / RAC2 GTPase cycle / RHOD GTPase cycle / RHOJ GTPase cycle / RAC3 GTPase cycle / RHOF GTPase cycle / FLT3 Signaling / RND3 GTPase cycle / RND2 GTPase cycle / RND1 GTPase cycle / PI3K events in ERBB4 signaling / Interleukin-7 signaling / GAB1 signalosome / PI3K events in ERBB2 signaling / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / IRS-mediated signalling / GPVI-mediated activation cascade / Signaling by SCF-KIT / Downstream signal transduction / PI3K/AKT activation / Role of phospholipids in phagocytosis / Tie2 Signaling / Role of LAT2/NTAL/LAB on calcium mobilization / Costimulation by the CD28 family / CD28 dependent PI3K/Akt signaling / RAF/MAP kinase cascade / Interleukin receptor SHC signaling / PI-3K cascade:FGFR1 / PI-3K cascade:FGFR2 / PI-3K cascade:FGFR3 / PI-3K cascade:FGFR4 / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / PI3K Cascade / PIP3 activates AKT signaling / GP1b-IX-V activation signalling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Synthesis of PIPs at the plasma membrane / RHOA GTPase cycle / DAP12 signaling / RHOU GTPase cycle / RHOV GTPase cycle / RHOG GTPase cycle / Regulation of signaling by CBL / Downstream TCR signaling / RET signaling / response to muscle inactivity / negative regulation of actin filament depolymerization / Interleukin-3, Interleukin-5 and GM-CSF signaling / VEGFA-VEGFR2 Pathway / response to L-leucine / regulation of actin filament organization / phosphatidylinositol 3-kinase regulator activity / response to butyrate / autosome genomic imprinting / cellular response to hydrostatic pressure / IRS-mediated signalling / phosphatidylinositol 3-kinase activator activity / PI3K events in ERBB4 signaling / 1-phosphatidylinositol-3-kinase regulator activity / Activated NTRK2 signals through PI3K / positive regulation of protein localization to membrane / Activated NTRK3 signals through PI3K / ErbB-3 class receptor binding / negative regulation of fibroblast apoptotic process / cardiac muscle cell contraction / phosphatidylinositol 3-kinase complex, class IB / vasculature development / transmembrane receptor protein tyrosine kinase adaptor activity / positive regulation of endoplasmic reticulum unfolded protein response / Signaling by cytosolic FGFR1 fusion mutants / regulation of cellular respiration / enzyme-substrate adaptor activity / phosphatidylinositol 3-kinase complex / anoikis / Nephrin family interactions / Extra-nuclear estrogen signaling / 1-phosphatidylinositol-4-phosphate 3-kinase activity / Costimulation by the CD28 family / 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity / vascular endothelial growth factor signaling pathway / PI3K/AKT activation / MET activates PI3K/AKT signaling / phosphatidylinositol-4,5-bisphosphate 3-kinase / G alpha (q) signalling events / phosphatidylinositol 3-kinase / phosphatidylinositol 3-kinase complex, class IA / relaxation of cardiac muscle / phosphatidylinositol-3-phosphate biosynthetic process / 1-phosphatidylinositol-3-kinase activity / negative regulation of macroautophagy / Signaling by ALK / PI-3K cascade:FGFR3 / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / protein kinase activator activity / response to dexamethasone / PI-3K cascade:FGFR2
Similarity search - Function
Ubiquitin-like (UB roll) - #770 / Helix Hairpins - #1490 / PI3Kalpha, catalytic domain / Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain / PIK3R1, inter-SH2 domain / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Phosphatidylinositol 3-/4-kinase, catalytic domain ...Ubiquitin-like (UB roll) - #770 / Helix Hairpins - #1490 / PI3Kalpha, catalytic domain / Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain / PIK3R1, inter-SH2 domain / PI3K p85 subunit, C-terminal SH2 domain / PI3K regulatory subunit p85-related , inter-SH2 domain / PI3K p85 subunit, N-terminal SH2 domain / Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain / Phosphatidylinositol 3-/4-kinase, catalytic domain / Phosphatidylinositol 3-kinase, accessory domain (PIK) / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 / PI3-kinase family, p85-binding domain / PI3-kinase family, p85-binding domain / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / C2 domain / Phosphatidylinositol 3-kinase, adaptor-binding domain / Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Phosphoinositide 3-kinase C2 / Phosphoinositide 3-kinase, region postulated to contain C2 domain / C2 phosphatidylinositol 3-kinase-type domain / C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile. / Phosphoinositide 3-kinase, accessory (PIK) domain superfamily / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Rho GTPase activation protein / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / C2 domain superfamily / SH2 domain / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / Ubiquitin-like (UB roll) / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Alpha Horseshoe / Helix Hairpins / Armadillo-type fold / Ubiquitin-like domain superfamily / Roll / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha / Alpha Beta
Similarity search - Domain/homology
Chem-5H2 / Phosphatidylinositol 3-kinase regulatory subunit alpha / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Similarity search - Component
Biological speciesHomo sapiens (human)
Bos taurus (cattle)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3 Å
AuthorsHeffron, T.P. / Heald, R.A. / Ndubaku, C. / Wei, B.Q. / Augustin, M. / Do, S. / Edgar, K. / Eigenbrot, C. / Friedman, L. / Gancia, E. ...Heffron, T.P. / Heald, R.A. / Ndubaku, C. / Wei, B.Q. / Augustin, M. / Do, S. / Edgar, K. / Eigenbrot, C. / Friedman, L. / Gancia, E. / Jackson, P.S. / Jones, G. / Kolesnikov, A. / Lee, L.B. / Lesnick, J.D. / Lewis, C. / McLean, N. / Mortle, M. / Nonomiya, J. / Pang, J. / Price, S. / Prior, W.W. / Salphati, L. / Sideris, S. / Staben, S. / Steinbacher, S. / Tsui, V. / Wallin, J. / Sampath, D. / Olivero, A.
CitationJournal: J.Med.Chem. / Year: 2016
Title: The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)- ...Title: The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
Authors: Heffron, T.P. / Heald, R.A. / Ndubaku, C. / Wei, B. / Augistin, M. / Do, S. / Edgar, K. / Eigenbrot, C. / Friedman, L. / Gancia, E. / Jackson, P.S. / Jones, G. / Kolesnikov, A. / Lee, L.B. / ...Authors: Heffron, T.P. / Heald, R.A. / Ndubaku, C. / Wei, B. / Augistin, M. / Do, S. / Edgar, K. / Eigenbrot, C. / Friedman, L. / Gancia, E. / Jackson, P.S. / Jones, G. / Kolesnikov, A. / Lee, L.B. / Lesnick, J.D. / Lewis, C. / McLean, N. / Mortl, M. / Nonomiya, J. / Pang, J. / Price, S. / Prior, W.W. / Salphati, L. / Sideris, S. / Staben, S.T. / Steinbacher, S. / Tsui, V. / Wallin, J. / Sampath, D. / Olivero, A.G.
History
DepositionSep 23, 2015Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jan 27, 2016Provider: repository / Type: Initial release
Revision 1.1Feb 24, 2016Group: Database references
Revision 1.2Mar 6, 2024Group: Data collection / Database references / Derived calculations
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list
Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
B: Phosphatidylinositol 3-kinase regulatory subunit alpha
D: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
E: Phosphatidylinositol 3-kinase regulatory subunit alpha
hetero molecules


Theoretical massNumber of molelcules
Total (without water)291,2936
Polymers290,3874
Non-polymers9062
Water0
1
A: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
B: Phosphatidylinositol 3-kinase regulatory subunit alpha
hetero molecules


Theoretical massNumber of molelcules
Total (without water)145,6463
Polymers145,1932
Non-polymers4531
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area4100 Å2
ΔGint-20 kcal/mol
Surface area50830 Å2
MethodPISA
2
D: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
E: Phosphatidylinositol 3-kinase regulatory subunit alpha
hetero molecules


Theoretical massNumber of molelcules
Total (without water)145,6463
Polymers145,1932
Non-polymers4531
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area3910 Å2
ΔGint-21 kcal/mol
Surface area50840 Å2
MethodPISA
Unit cell
Length a, b, c (Å)92.660, 121.830, 166.360
Angle α, β, γ (deg.)90.00, 102.33, 90.00
Int Tables number4
Space group name H-MP1211

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Components

#1: Protein Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / PtdIns-3-kinase subunit alpha / Phosphatidylinositol 4 / 5-bisphosphate 3-kinase 110 kDa catalytic ...PtdIns-3-kinase subunit alpha / Phosphatidylinositol 4 / 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha / p110alpha / Phosphoinositide-3-kinase catalytic alpha polypeptide / Serine/threonine protein kinase PIK3CA


Mass: 124313.797 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: PIK3CA / Production host: Spodoptera frugiperda (fall armyworm)
References: UniProt: P42336, phosphatidylinositol-4,5-bisphosphate 3-kinase, non-specific serine/threonine protein kinase
#2: Protein Phosphatidylinositol 3-kinase regulatory subunit alpha / PtdIns-3-kinase regulatory subunit alpha / Phosphatidylinositol 3-kinase 85 kDa regulatory subunit ...PtdIns-3-kinase regulatory subunit alpha / Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha / PtdIns-3-kinase regulatory subunit p85-alpha


Mass: 20879.555 Da / Num. of mol.: 2 / Fragment: UNP residues 431-599
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Bos taurus (cattle) / Gene: PIK3R1 / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P23727
#3: Chemical ChemComp-5H2 / methyl {2-[4-(2-chlorophenyl)-4H-1,2,4-triazol-3-yl]-4,5-dihydrothieno[3,2-d][1]benzoxepin-8-yl}carbamate


Mass: 452.913 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C22H17ClN4O3S

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION

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Sample preparation

CrystalDensity Matthews: 3.4 Å3/Da / Density % sol: 63.85 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / Details: PEG 20000 / PH range: 6.5

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Data collection

DiffractionMean temperature: 110 K
Diffraction sourceSource: SYNCHROTRON / Site: SLS / Beamline: X06SA / Wavelength: 1 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Jul 3, 2009
RadiationMonochromator: Si(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 3→50 Å / Num. obs: 70505 / % possible obs: 97.5 % / Redundancy: 2.9 % / Biso Wilson estimate: 110.38 Å2 / Rsym value: 0.066 / Net I/σ(I): 12.2
Reflection shellResolution: 3→3.11 Å / Redundancy: 3 % / Rmerge(I) obs: 0.411 / Mean I/σ(I) obs: 2.7 / % possible all: 97.8

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Processing

Software
NameVersionClassification
BUSTER2.11.5refinement
XDSdata reduction
SCALAdata scaling
MOLREPphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 3→49.5 Å / Cor.coef. Fo:Fc: 0.9304 / Cor.coef. Fo:Fc free: 0.9069 / Cross valid method: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 2.672 / SU Rfree Blow DPI: 0.322
RfactorNum. reflection% reflectionSelection details
Rfree0.2182 3490 4.95 %RANDOM
Rwork0.1808 ---
obs0.1826 70504 97.35 %-
Displacement parametersBiso mean: 102.09 Å2
Baniso -1Baniso -2Baniso -3
1--25.9279 Å20 Å2-9.2012 Å2
2--5.0779 Å20 Å2
3---20.8501 Å2
Refine analyzeLuzzati coordinate error obs: 0.636 Å
Refinement stepCycle: LAST / Resolution: 3→49.5 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms18271 0 62 0 18333
Refine LS restraints
Refine-IDTypeDev idealNumberRestraint functionWeight
X-RAY DIFFRACTIONt_bond_d0.0118726HARMONIC2
X-RAY DIFFRACTIONt_angle_deg1.1625272HARMONIC2
X-RAY DIFFRACTIONt_dihedral_angle_d6797SINUSOIDAL2
X-RAY DIFFRACTIONt_incorr_chiral_ct
X-RAY DIFFRACTIONt_pseud_angle
X-RAY DIFFRACTIONt_trig_c_planes529HARMONIC2
X-RAY DIFFRACTIONt_gen_planes2605HARMONIC5
X-RAY DIFFRACTIONt_it18726HARMONIC20
X-RAY DIFFRACTIONt_nbd
X-RAY DIFFRACTIONt_omega_torsion2.62
X-RAY DIFFRACTIONt_other_torsion22.01
X-RAY DIFFRACTIONt_improper_torsion
X-RAY DIFFRACTIONt_chiral_improper_torsion2382SEMIHARMONIC5
X-RAY DIFFRACTIONt_sum_occupancies
X-RAY DIFFRACTIONt_utility_distance
X-RAY DIFFRACTIONt_utility_angle
X-RAY DIFFRACTIONt_utility_torsion
X-RAY DIFFRACTIONt_ideal_dist_contact21270SEMIHARMONIC4
LS refinement shellResolution: 3→3.08 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0.3286 230 4.51 %
Rwork0.2637 4870 -
all0.2667 5100 -
obs--97.35 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.2240.5584-0.66750.805-0.69562.70130.2284-0.39160.42050.4764-0.1510.008-0.33610.1955-0.0775-0.1370.0446-0.0145-0.0553-0.0042-0.007817.57016.700935.2774
22.0407-2.22180.13836.9508-3.46483.24460.036-0.00410.5163-0.4492-0.3401-0.49340.0974-0.03050.3041-0.13320.1160.1177-0.3040.18090.082411.41632.5266-1.0464
33.2485-2.5446-1.51892.5502-1.98781.85730.0110.12640.2886-0.1937-0.1918-0.34810.54690.45020.1809-0.09550.15010.05550.03040.0248-0.191445.9732-18.648214.9628
43.3537-0.8409-2.63550.90110.08463.50380.00870.10480.1596-0.3219-0.159-0.37860.270.44050.1503-0.2190.1160.0763-0.04610.18090.071939.68582.67780.2457
52.181-0.6026-0.14530.8977-0.31982.53670.0896-0.0306-0.06060.1415-0.11630.34560.1646-0.56380.0267-0.1536-0.00040.0024-0.0360.03420.02671.88264.126916.0415
63.05551.5807-0.548701.34792.9247-0.13930.13710.0833-0.28140.07090.0792-0.06940.24280.06840.04210.050.0333-0.04670.0186-0.053913.61943.4634-2.2367
74.6310.5891-0.22982.08730.01663.7455-0.1290.6054-0.4012-0.57710.06110.09150.1128-0.2210.06790.04840.0360.0174-0.2116-0.0341-0.22848.5306-2.5502-15.2272
82.11550.82910.21610.5397-0.08152.9395-0.18010.4155-0.1715-0.40330.1511-0.3619-0.23920.64790.029-0.1038-0.14230.0510.1123-0.0605-0.192356.170815.1616-85.2057
92.04011.9010.028.3155-0.09972.82920.14740.3149-0.20590.27220.09810.61660.4177-0.1833-0.2455-0.0416-0.1552-0.1637-0.304-0.0019-0.055723.2986-12.7224-71.5955
101.62232.90310.92944.4293-0.43275.72490.1667-0.08540.2127-0.2356-0.1950.0302-0.52980.23480.02830.178-0.13220.0268-0.1967-0.1067-0.315353.816937.0275-48.5405
111.02880.3733-0.60251.10610.0985.53030.2652-0.25-0.10650.486-0.07970.0254-0.4630.2172-0.18550.0797-0.1615-0.0361-0.18380.0272-0.145238.751315.9301-47.4656
122.63880.37550.15610.56190.18044.0138-0.02550.44560.2922-0.58250.14580.1164-0.3787-0.254-0.12020.099-0.0585-0.088-0.12390.082-0.110231.311816.7554-87.5661
136.4436-1.0361.52370.97350.65640.44520.1421-0.12-0.48230.00690.13070.5585-0.0673-0.077-0.27280.0633-0.0168-0.0465-0.21660.0516-0.008922.156216.3461-67.7913
144.2303-0.29032.07931.7822-0.89234.06070.0508-0.3437-0.0240.30970.30370.6248-0.4828-0.6322-0.3545-0.13310.1060.0872-0.22510.16730.03448.97722.2992-64.4282
151.7348-0.1914-1.5522.82982.80844.7579-0.0189-0.0583-0.2066-0.0047-0.1103-0.03340.47640.11020.12930.05730.1331-0.063-0.14850.1029-0.248519.1277-16.560437.4481
162.0847-0.5645-1.20191.02381.25943.3614-0.17370.52490.3180.13760.1456-0.0658-0.5992-0.14360.02810.3403-0.1809-0.0265-0.10310.116-0.21556.239339.513-83.1148
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1{A|2 - A|167 A|298 - A|306}
2X-RAY DIFFRACTION2{A|168 - A|297}
3X-RAY DIFFRACTION3{A|323 - A|489}
4X-RAY DIFFRACTION4{A|490 - A|695}
5X-RAY DIFFRACTION5{A|696 - A|804}
6X-RAY DIFFRACTION6{A|805 - A|853}
7X-RAY DIFFRACTION7{A|854 - A|1062}
8X-RAY DIFFRACTION8{D|2 - D|167 D|298 - D|307}
9X-RAY DIFFRACTION9{D|168 - D|297}
10X-RAY DIFFRACTION10{D|323 - D|489}
11X-RAY DIFFRACTION11{D|490 - D|695}
12X-RAY DIFFRACTION12{D|696 - D|804}
13X-RAY DIFFRACTION13{D|805 - D|853}
14X-RAY DIFFRACTION14{D|854 - D|1062}
15X-RAY DIFFRACTION15{B|457 - B|577}
16X-RAY DIFFRACTION16{E|450 - E|574}

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