Entry | Database: PDB / ID: 5do2 |
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Title | Complex structure of MERS-RBD bound with 4C2 antibody |
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Components | - 4C2 heavy chain
- 4C2 light chain
- S protein
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Keywords | VIRAL PROTEIN/IMMUNE SYSTEM / receptor-binding domain of MERS-CoV spike / 4C2 antibody / neuralization / receptor-binding blocking. / VIRAL PROTEIN-IMMUNE SYSTEM complex |
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Function / homology | Function and homology information
: / endocytosis involved in viral entry into host cell / membrane => GO:0016020 / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / symbiont entry into host cell / fusion of virus membrane with host plasma membrane ...: / endocytosis involved in viral entry into host cell / membrane => GO:0016020 / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / symbiont entry into host cell / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / host cell plasma membrane / virion membrane / membraneSimilarity search - Function ubp-family deubiquitinating enzyme fold - #30 / : / Spike protein, C-terminal core receptor binding subdomain / ubp-family deubiquitinating enzyme fold / Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV / Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Single Sheet / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. ...ubp-family deubiquitinating enzyme fold - #30 / : / Spike protein, C-terminal core receptor binding subdomain / ubp-family deubiquitinating enzyme fold / Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV / Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Single Sheet / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal / Alpha-Beta Plaits / Immunoglobulins / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_virus.gif) Middle East respiratory syndrome coronavirus
![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.409 Å |
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Authors | Li, Y. / Wan, Y. / Liu, P. / Zhao, J. / Lu, G. / Qi, J. / Wang, Q. / Lu, X. / Wu, Y. / Liu, W. ...Li, Y. / Wan, Y. / Liu, P. / Zhao, J. / Lu, G. / Qi, J. / Wang, Q. / Lu, X. / Wu, Y. / Liu, W. / Yuen, K.Y. / Perlman, S. / Gao, G.F. / Yan, J. |
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Citation | Journal: Cell Res. / Year: 2015 Title: A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. Authors: Li, Y. / Wan, Y. / Liu, P. / Zhao, J. / Lu, G. / Qi, J. / Wang, Q. / Lu, X. / Wu, Y. / Liu, W. / Zhang, B. / Yuen, K.Y. / Perlman, S. / Gao, G.F. / Yan, J. |
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History | Deposition | Sep 10, 2015 | Deposition site: RCSB / Processing site: PDBJ |
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Revision 1.0 | Oct 14, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 11, 2015 | Group: Database references |
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Revision 1.2 | Feb 19, 2020 | Group: Data collection / Derived calculations / Category: chem_comp / diffrn_source / pdbx_struct_oper_list Item: _chem_comp.type / _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.3 | Jul 29, 2020 | Group: Data collection / Derived calculations / Structure summary Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _entity.pdbx_description ..._chem_comp.name / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.4 | Nov 8, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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