Entry Database : PDB / ID : 5arf Structure visualization Downloads & linksTitle SMYD2 in complex with small molecule inhibitor compound-2 ComponentsN-LYSINE METHYLTRANSFERASE SMYD2 Details Keywords TRANSFERASE / METHYLTRANSFERASE / SET DOMAIN / SMALL MOLECULE INHIBITOR / SGC PROBE / DRUG TARGETFunction / homology Function and homology informationFunction Domain/homology Component
lysine N-methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / regulation of DNA damage response, signal transduction by p53 class mediator / RNA polymerase II complex binding ... lysine N-methyltransferase activity / [histone H3]-lysine4 N-trimethyltransferase / peptidyl-lysine monomethylation / peptidyl-lysine dimethylation / histone H3K4 trimethyltransferase activity / histone H3K36 methyltransferase activity / protein-lysine N-methyltransferase activity / histone H3 methyltransferase activity / regulation of DNA damage response, signal transduction by p53 class mediator / RNA polymerase II complex binding / Transferases; Transferring one-carbon groups; Methyltransferases / regulation of signal transduction by p53 class mediator / Regulation of TP53 Activity through Methylation / PKMTs methylate histone lysines / p53 binding / heart development / negative regulation of cell population proliferation / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding / cytosol / cytoplasm Similarity search - Function SMYD2, SET domain / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / Beta-clip-like / SET domain / Tetratricopeptide repeat domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain ... SMYD2, SET domain / : / MYND finger / Zinc finger, MYND-type / Zinc finger MYND-type signature. / Zinc finger MYND-type profile. / Beta-clip-like / SET domain / Tetratricopeptide repeat domain / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain / Beta Complex / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Tetratricopeptide-like helical domain superfamily / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.92 Å DetailsAuthors Hillig, R.C. / Badock, V. / Barak, N. / Stellfeld, T. / Eggert, E. / ter Laak, A. / Weiske, J. / Christ, C.D. / Koehr, S. / Stoeckigt, D. ...Hillig, R.C. / Badock, V. / Barak, N. / Stellfeld, T. / Eggert, E. / ter Laak, A. / Weiske, J. / Christ, C.D. / Koehr, S. / Stoeckigt, D. / Mowat, J. / Mueller, T. / Fernandez-Montalvan, A.E. / Hartung, I.V. / Stresemann, C. / Brumby, T. / Weinmann, H. CitationJournal : J.Med.Chem. / Year : 2016Title : Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) for the Protein Lysine Methyltransferase Smyd2.Authors: Eggert, E. / Hillig, R.C. / Kohr, S. / Stockigt, D. / Weiske, J. / Barak, N. / Mowat, J. / Brumby, T. / Christ, C.D. / Ter Laak, A. / Lang, T. / Fernandez-Montalvan, A.E. / Badock, V. / ... Authors : Eggert, E. / Hillig, R.C. / Kohr, S. / Stockigt, D. / Weiske, J. / Barak, N. / Mowat, J. / Brumby, T. / Christ, C.D. / Ter Laak, A. / Lang, T. / Fernandez-Montalvan, A.E. / Badock, V. / Weinmann, H. / Hartung, I.V. / Barsyte-Lovejoy, D. / Szewczyk, M. / Kennedy, S. / Li, F. / Vedadi, M. / Brown, P.J. / Santhakumar, V. / Arrowsmith, C.H. / Stellfeld, T. / Stresemann, C. History Deposition Sep 24, 2015 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 27, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jun 8, 2016 Group : Database referencesRevision 1.2 Sep 13, 2017 Group : Data collection / Category : diffrn_detector / Item : _diffrn_detector.typeRevision 1.3 Jan 10, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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