登録情報 データベース : PDB / ID : 4zsp 構造の表示 ダウンロードとリンクタイトル BACE crystal structure with bicyclic aminothiazine inhibitor 要素Beta-secretase 1 詳細 キーワード Hydrolase/Hydrolase Inhibitor / aspartyl / protease / beta-secretase / Hydrolase-Hydrolase Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.91 Å 詳細データ登録者 Timm, D.E. 引用ジャーナル : Bioorg.Med.Chem. / 年 : 2015タイトル : Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.著者: Winneroski, L.L. / Schiffler, M.A. / Erickson, J.A. / May, P.C. / Monk, S.A. / Timm, D.E. / Audia, J.E. / Beck, J.P. / Boggs, L.N. / Borders, A.R. / Boyer, R.D. / Brier, R.A. / Hudziak, K.J. ... 著者 : Winneroski, L.L. / Schiffler, M.A. / Erickson, J.A. / May, P.C. / Monk, S.A. / Timm, D.E. / Audia, J.E. / Beck, J.P. / Boggs, L.N. / Borders, A.R. / Boyer, R.D. / Brier, R.A. / Hudziak, K.J. / Klimkowski, V.J. / Garcia Losada, P. / Mathes, B.M. / Stout, S.L. / Watson, B.M. / Mergott, D.J. 履歴 登録 2015年5月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年6月10日 Provider : repository / タイプ : Initial release改定 1.1 2015年6月17日 Group : Database references
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