- PDB-4wyk: Structure of the LRR and NTF2-like domains of NXF1 complexed with NXT1 -
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Basic information
Entry
Database: PDB / ID: 4wyk
Title
Structure of the LRR and NTF2-like domains of NXF1 complexed with NXT1
Components
NTF2-related export protein 1
Nuclear RNA export factor 1
Keywords
TRANSPORT PROTEIN / nuclear export
Function / homology
Function and homology information
nuclear RNA export factor complex / nuclear pore central transport channel / nuclear inclusion body / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / Transport of Mature mRNA derived from an Intron-Containing Transcript / poly(A)+ mRNA export from nucleus / mRNA export from nucleus / nuclear pore ...nuclear RNA export factor complex / nuclear pore central transport channel / nuclear inclusion body / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / Transport of Mature mRNA derived from an Intron-Containing Transcript / poly(A)+ mRNA export from nucleus / mRNA export from nucleus / nuclear pore / protein export from nucleus / small GTPase binding / cytoplasmic stress granule / protein transport / nuclear speck / mRNA binding / RNA binding / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function
Nuclear RNA export factor Tap, RNA-binding domain / Tap, RNA-binding / Nuclear transport factor 2/Mtr2 / TAP C-terminal (TAP-C) domain / TAP C-terminal domain / TAP C-terminal (TAP-C) domain profile. / C-terminal domain of vertebrate Tap protein / Nuclear RNA export factor / Nuclear transport factor 2, eukaryote / Nuclear transport factor 2 domain profile. ...Nuclear RNA export factor Tap, RNA-binding domain / Tap, RNA-binding / Nuclear transport factor 2/Mtr2 / TAP C-terminal (TAP-C) domain / TAP C-terminal domain / TAP C-terminal (TAP-C) domain profile. / C-terminal domain of vertebrate Tap protein / Nuclear RNA export factor / Nuclear transport factor 2, eukaryote / Nuclear transport factor 2 domain profile. / Nuclear transport factor 2 domain / Nuclear transport factor 2 (NTF2) domain / Nuclear Transport Factor 2; Chain: A, - #50 / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Alpha-Beta Horseshoe / UBA-like superfamily / NTF2-like domain superfamily / Leucine-rich repeat profile. / Nuclear Transport Factor 2; Chain: A, / Leucine-rich repeat / Leucine-rich repeat domain superfamily / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / Roll / Alpha Beta Similarity search - Domain/homology
NuclearRNAexportfactor1 / Tip-associated protein / Tip-associating protein / mRNA export factor TAP
Mass: 52085.277 Da / Num. of mol.: 2 / Fragment: UNP residues 96-555 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: NXF1, TAP / Production host: Escherichia coli (E. coli) / References: UniProt: Q9UBU9
#2: Protein
NTF2-relatedexportprotein1 / Protein p15
Mass: 15728.561 Da / Num. of mol.: 2 / Fragment: UNP residues 2-140 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: NXT1 / Production host: Escherichia coli (E. coli) / References: UniProt: Q9UKK6
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION
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Sample preparation
Crystal
Density Matthews: 2.95 Å3/Da / Density % sol: 58.25 %
Crystal grow
Temperature: 291 K / Method: vapor diffusion, sitting drop Details: 9 % PEG 6000, 1 M LiCl, 0.1 M sodium citrate buffer pH 5.1 See publication for full details. PH range: 5.1
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