登録情報 データベース : PDB / ID : 4wrs 構造の表示 ダウンロードとリンクタイトル Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor. 要素Serine/threonine-protein kinase pim-1 詳細 キーワード transferase/transferase inhibitor / TRANSFERASE / serine/threonine protein kinase / transferase-transferase inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins ... positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / vitamin D receptor signaling pathway / cellular detoxification / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / Signaling by FLT3 fusion proteins / positive regulation of TORC1 signaling / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / nucleolus / negative regulation of apoptotic process / apoptotic process / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ... Serine/threonine-protein kinase pim-1/2/3 / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-3U1 / Serine/threonine-protein kinase pim-1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Mohr, C. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2015タイトル : The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.著者: Wang, H.L. / Cee, V.J. / Chavez, F. / Lanman, B.A. / Reed, A.B. / Wu, B. / Guerrero, N. / Lipford, J.R. / Sastri, C. / Winston, J. / Andrews, K.L. / Huang, X. / Lee, M.R. / Mohr, C. / Xu, Y. ... 著者 : Wang, H.L. / Cee, V.J. / Chavez, F. / Lanman, B.A. / Reed, A.B. / Wu, B. / Guerrero, N. / Lipford, J.R. / Sastri, C. / Winston, J. / Andrews, K.L. / Huang, X. / Lee, M.R. / Mohr, C. / Xu, Y. / Zhou, Y. / Tasker, A.S. 履歴 登録 2014年10月25日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年2月4日 Provider : repository / タイプ : Initial release改定 1.1 2015年2月11日 Group : Database references改定 1.2 2023年12月27日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Source and taxonomy / Structure summary カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / entity_src_gen / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_keywords Item : _citation.journal_id_CSD / _database_2.pdbx_DOI ... _citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation / _struct_keywords.text
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