登録情報 | データベース: PDB / ID: 4w9w |
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タイトル | Crystal Structure of BMP-2-inducible kinase in complex with small molecule AZD-7762 |
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要素 | BMP-2-inducible protein kinase |
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キーワード | TRANSFERASE / kinase / small-molecule / catalytic domain / protein binding / inhibitor / Structural Genomics / Structural Genomics Consortium / SGC |
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機能・相同性 | 機能・相同性情報
phosphatase regulator activity / regulation of clathrin-dependent endocytosis / AP-2 adaptor complex binding / regulation of bone mineralization / positive regulation of Notch signaling pathway / non-specific serine/threonine protein kinase / nuclear speck / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding ...phosphatase regulator activity / regulation of clathrin-dependent endocytosis / AP-2 adaptor complex binding / regulation of bone mineralization / positive regulation of Notch signaling pathway / non-specific serine/threonine protein kinase / nuclear speck / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / nucleus / cytoplasm類似検索 - 分子機能 BMP-2-inducible protein kinase, C-terminal / BMP-2-inducible protein kinase C-terminus / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase domain profile. ...BMP-2-inducible protein kinase, C-terminal / BMP-2-inducible protein kinase C-terminus / : / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.72 Å |
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データ登録者 | Sorrell, F.J. / Elkins, J.M. / Krojer, T. / Savitsky, P. / Williams, E. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: Structure / 年: 2016 タイトル: Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. 著者: Sorrell, F.J. / Szklarz, M. / Abdul Azeez, K.R. / Elkins, J.M. / Knapp, S. |
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履歴 | 登録 | 2014年8月28日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2014年9月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年3月2日 | Group: Database references |
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改定 1.2 | 2016年3月9日 | Group: Database references |
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改定 1.3 | 2018年1月24日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
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改定 1.4 | 2024年5月8日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / diffrn_radiation_wavelength Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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