登録情報 データベース : PDB / ID : 4px5 構造の表示 ダウンロードとリンクタイトル Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate 要素Glucokinase regulatory protein 詳細 キーワード sugar binding protein/inhibitor / SIS domain containing protein / Regulatory protein - binds to and inhibits glucokinase / glucokinase / sugar binding protein-inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
amino sugar catabolic process / ether hydrolase activity / carbon-oxygen lyase activity / negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / urate metabolic process / kinase inhibitor activity / peptidoglycan turnover / Regulation of Glucokinase by Glucokinase Regulatory Protein ... amino sugar catabolic process / ether hydrolase activity / carbon-oxygen lyase activity / negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / urate metabolic process / kinase inhibitor activity / peptidoglycan turnover / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis / enzyme inhibitor activity / response to glucose / protein import into nucleus / glucose homeostasis / carbohydrate binding / enzyme binding / mitochondrion / nucleoplasm / cytoplasm / cytosol 類似検索 - 分子機能 C-terminal lid domain of glucokinase regulatory protein / Glucokinase regulatory protein, conserved site / N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein / Glucokinase regulatory protein family signature. / SIS domain / SIS domain profile. / SIS domain superfamily / Glucose-6-phosphate isomerase like protein; domain 1 / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 Chem-2WZ / IODIDE ION / D-SORBITOL-6-PHOSPHATE / Glucokinase regulatory protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Jordan, S.R. / Chmait, S. 引用ジャーナル : To be Published タイトル : Discovery and Structure Guided Optimization of Diarylmethanesulfonamide Disruptors of GK-GKRP Binding著者 : Pennington, L.D. / Bartberger, M.D. / Croghan, M.D. / Andrews, K.L. / Ashton, K.S. / Bourbeau, M.P. / Chen, J. / Chmait, S. / Cupple, R. / Fotsch, C. 履歴 登録 2014年3月21日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年5月13日 Provider : repository / タイプ : Initial release改定 1.1 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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