Entry | Database: PDB / ID: 4psq |
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Title | Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with a non-retinoid ligand |
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Components | Retinol-binding protein 4 |
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Keywords | TRANSPORT PROTEIN / retinol binding / disease mutation / secreted / sensory transduction / vision / Vitamin A |
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Function / homology | Function and homology information
Retinoid metabolism disease events / urinary bladder development / embryonic retina morphogenesis in camera-type eye / retinol transport / female genitalia morphogenesis / retinol transmembrane transporter activity / embryonic organ morphogenesis / maintenance of gastrointestinal epithelium / embryonic skeletal system development / negative regulation of cardiac muscle cell proliferation ...Retinoid metabolism disease events / urinary bladder development / embryonic retina morphogenesis in camera-type eye / retinol transport / female genitalia morphogenesis / retinol transmembrane transporter activity / embryonic organ morphogenesis / maintenance of gastrointestinal epithelium / embryonic skeletal system development / negative regulation of cardiac muscle cell proliferation / eye development / heart trabecula formation / retinal binding / cardiac muscle tissue development / retinol metabolic process / retinol binding / positive regulation of immunoglobulin production / Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / uterus development / vagina development / response to retinoic acid / Retinoid metabolism and transport / visual perception / gluconeogenesis / lung development / positive regulation of insulin secretion / glucose homeostasis / heart development / extracellular space / extracellular exosome / extracellular regionSimilarity search - Function Retinol binding protein/Purpurin / Lipocalin, ApoD type / Lipocalin family conserved site / Calycin beta-barrel core domain / Lipocalin / cytosolic fatty-acid binding protein family / Lipocalin/cytosolic fatty-acid binding domain / Calycin / Lipocalin / Lipocalin signature. / Beta Barrel / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.4 Å |
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Authors | Wang, Z. / Johnstone, S. / Walker, N. |
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Citation | Journal: Bioorg.Med.Chem.Lett. / Year: 2014 Title: Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Authors: Wang, Y. / Connors, R. / Fan, P. / Wang, X. / Wang, Z. / Liu, J. / Kayser, F. / Medina, J.C. / Johnstone, S. / Xu, H. / Thibault, S. / Walker, N. / Conn, M. / Zhang, Y. / Liu, Q. / Grillo, M. ...Authors: Wang, Y. / Connors, R. / Fan, P. / Wang, X. / Wang, Z. / Liu, J. / Kayser, F. / Medina, J.C. / Johnstone, S. / Xu, H. / Thibault, S. / Walker, N. / Conn, M. / Zhang, Y. / Liu, Q. / Grillo, M.P. / Motani, A. / Coward, P. / Wang, Z. |
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History | Deposition | Mar 7, 2014 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jul 2, 2014 | Provider: repository / Type: Initial release |
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