- PDB-4oz3: Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole -
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データを開く
IDまたはキーワード:
読み込み中...
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基本情報
登録情報
データベース: PDB / ID: 4oz3
タイトル
Human solAC Complexed with 4-phenyl-3-(trifluoromethyl)-1H-pyrazole
要素
Adenylate cyclase type 10
キーワード
LYASE / protein-ligand complex
機能・相同性
機能・相同性情報
negative regulation of cardiac muscle cell contraction / astrocyte end-foot / mitochondrial ATP transmembrane transport / bicarbonate binding / epithelial cilium movement involved in extracellular fluid movement / neuron projection retraction / positive regulation of glycogen catabolic process / : / central region of growth cone / glucose catabolic process ...negative regulation of cardiac muscle cell contraction / astrocyte end-foot / mitochondrial ATP transmembrane transport / bicarbonate binding / epithelial cilium movement involved in extracellular fluid movement / neuron projection retraction / positive regulation of glycogen catabolic process / : / central region of growth cone / glucose catabolic process / regulation of mitophagy / regulation of membrane repolarization / adenylate cyclase / basal part of cell / positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cAMP biosynthetic process / positive regulation of ossification / adenylate cyclase activity / positive regulation of protein targeting to mitochondrion / positive regulation of reactive oxygen species biosynthetic process / neuron projection extension / positive regulation of vascular associated smooth muscle cell apoptotic process / positive regulation of mitochondrial depolarization / positive regulation of ATP biosynthetic process / positive regulation of cardiac muscle hypertrophy / positive regulation of cardiac muscle cell apoptotic process / negative regulation of mitochondrial membrane potential / spermatid development / positive regulation of axon extension / Hedgehog 'off' state / negative regulation of reactive oxygen species biosynthetic process / neuron projection maintenance / positive regulation of peptidyl-threonine phosphorylation / cilium / manganese ion binding / ATPase binding / cytoskeleton / intracellular signal transduction / apical plasma membrane / neuronal cell body / dendrite / perinuclear region of cytoplasm / magnesium ion binding / mitochondrion / extracellular region / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
温度: 277 K / 手法: 蒸気拡散法, ハンギングドロップ法 詳細: 1ul of protein solution was mixed with 1ul of reservoir solution (0.1M sodium acetate, pH 4.8, 0.2M trisodium citrate, 16-18% PEG4K and 10% glycerol) and left to equilibrate at 4C
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データ収集
回折
平均測定温度: 100 K
放射光源
由来: シンクロトロン / サイト: ESRF / ビームライン: ID29 / 波長: 1 Å
検出器
タイプ: ADSC QUANTUM 4 / 検出器: CCD / 日付: 2006年2月20日
放射
プロトコル: SINGLE WAVELENGTH / 散乱光タイプ: x-ray
放射波長
波長: 1 Å / 相対比: 1
反射
解像度: 1.7→27.22 Å / Num. obs: 56523 / % possible obs: 94.27 % / 冗長度: 2.6 % / Biso Wilson estimate: 23.64 Å2 / Net I/σ(I): 12.5
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解析
ソフトウェア
名称: BUSTER / バージョン: 2.11.5 / 分類: 精密化
精密化
解像度: 1.7→27.22 Å / Cor.coef. Fo:Fc: 0.9562 / Cor.coef. Fo:Fc free: 0.9341 / SU R Cruickshank DPI: 0.101 / 交差検証法: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 0.108 / SU Rfree Blow DPI: 0.108 / SU Rfree Cruickshank DPI: 0.104