- PDB-4oyi: Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone -
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基本情報
登録情報
データベース: PDB / ID: 4oyi
タイトル
Human solAC Complexed with (4-Amino-furazan-3-yl)-phenyl-methanone
要素
Adenylate cyclase type 10
キーワード
LYASE
機能・相同性
機能・相同性情報
negative regulation of cardiac muscle cell contraction / astrocyte end-foot / mitochondrial ATP transmembrane transport / bicarbonate binding / epithelial cilium movement involved in extracellular fluid movement / neuron projection retraction / positive regulation of glycogen catabolic process / : / central region of growth cone / glucose catabolic process ...negative regulation of cardiac muscle cell contraction / astrocyte end-foot / mitochondrial ATP transmembrane transport / bicarbonate binding / epithelial cilium movement involved in extracellular fluid movement / neuron projection retraction / positive regulation of glycogen catabolic process / : / central region of growth cone / glucose catabolic process / regulation of mitophagy / regulation of membrane repolarization / adenylate cyclase / basal part of cell / positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway / cAMP biosynthetic process / positive regulation of ossification / adenylate cyclase activity / positive regulation of protein targeting to mitochondrion / positive regulation of reactive oxygen species biosynthetic process / neuron projection extension / positive regulation of vascular associated smooth muscle cell apoptotic process / positive regulation of mitochondrial depolarization / positive regulation of ATP biosynthetic process / positive regulation of cardiac muscle hypertrophy / positive regulation of cardiac muscle cell apoptotic process / negative regulation of mitochondrial membrane potential / spermatid development / positive regulation of axon extension / Hedgehog 'off' state / negative regulation of reactive oxygen species biosynthetic process / neuron projection maintenance / positive regulation of peptidyl-threonine phosphorylation / cilium / manganese ion binding / ATPase binding / cytoskeleton / intracellular signal transduction / apical plasma membrane / neuronal cell body / dendrite / perinuclear region of cytoplasm / magnesium ion binding / mitochondrion / extracellular region / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
温度: 277 K / 手法: 蒸気拡散法, ハンギングドロップ法 詳細: 1ul of protein solution was mixed with 1ul of reservoir solution (0.1M sodium acetate, pH 4.8, 0.2M trisodium citrate, 16-18% PEG4K and 10% glycerol) and left to equilibrate at 4C
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データ収集
回折
平均測定温度: 100 K
放射光源
由来: シンクロトロン / サイト: ESRF / ビームライン: ID29 / 波長: 1 Å
検出器
タイプ: ADSC QUANTUM 4 / 検出器: CCD / 日付: 2006年2月20日
放射
プロトコル: SINGLE WAVELENGTH / 散乱光タイプ: x-ray
放射波長
波長: 1 Å / 相対比: 1
反射
解像度: 1.7→28.63 Å / Num. obs: 56679 / % possible obs: 95.1 % / 冗長度: 2.6 % / Net I/σ(I): 15.7
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解析
ソフトウェア
名称: REFMAC / バージョン: 5.8.0064 / 分類: 精密化
精密化
解像度: 1.7→28.58 Å / Cor.coef. Fo:Fc: 0.964 / Cor.coef. Fo:Fc free: 0.946 / SU B: 4.12 / SU ML: 0.071 / 交差検証法: THROUGHOUT / ESU R: 0.105 / ESU R Free: 0.105 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.20745
2813
5 %
RANDOM
Rwork
0.16964
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obs
0.17154
53866
94.92 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: BABINET MODEL WITH MASK