登録情報 | データベース: PDB / ID: 4j5a |
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タイトル | Human Cyclophilin D Complexed with an Inhibitor |
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要素 | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
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キーワード | Isomerase/Isomerase Inhibitor / Isomerase-Isomerase Inhibitor complex |
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機能・相同性 | 機能・相同性情報
regulation of proton-transporting ATPase activity, rotational mechanism / negative regulation of oxidative phosphorylation uncoupler activity / mitochondrial outer membrane permeabilization involved in programmed cell death / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / skeletal muscle fiber differentiation / mitochondrial permeability transition pore complex / mitochondrial depolarization / cellular response to arsenic-containing substance / negative regulation of ATP-dependent activity / negative regulation of oxidative phosphorylation ...regulation of proton-transporting ATPase activity, rotational mechanism / negative regulation of oxidative phosphorylation uncoupler activity / mitochondrial outer membrane permeabilization involved in programmed cell death / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / skeletal muscle fiber differentiation / mitochondrial permeability transition pore complex / mitochondrial depolarization / cellular response to arsenic-containing substance / negative regulation of ATP-dependent activity / negative regulation of oxidative phosphorylation / regulation of mitochondrial membrane permeability / cyclosporin A binding / negative regulation of release of cytochrome c from mitochondria / apoptotic mitochondrial changes / necroptotic process / protein peptidyl-prolyl isomerization / negative regulation of intrinsic apoptotic signaling pathway / cellular response to calcium ion / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / response to ischemia / cellular response to hydrogen peroxide / protein folding / mitochondrial inner membrane / mitochondrial matrix / negative regulation of apoptotic process / mitochondrion / membrane / cytoplasm類似検索 - 分子機能 Cyclophilin-like / Cyclophilin / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 Chem-67Z / Peptidyl-prolyl cis-trans isomerase F, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 同系置換 / 解像度: 1.58 Å |
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データ登録者 | Gelin, M. / Colliandre, L. / Bessin, Y. / Guichou, J.F. |
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引用 | ジャーナル: to be published タイトル: Rationnal Design of small-molecule inhibitors of human Cyclophilins and HCV replication. 著者: Colliandre, L. / Hamed-Belkacem, H. / Gelin, M. / Bessin, Y. / Douguet, D. / Bourguet, W. / Pawlotsky, J.M. / Guichou, J.F. |
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履歴 | 登録 | 2013年2月8日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年2月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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