登録情報 | データベース: PDB / ID: 4hcu |
---|
タイトル | Crystal structure of ITK in complext with compound 40 |
---|
要素 | Tyrosine-protein kinase ITK/TSK |
---|
キーワード | transferase/transferase inhibitor / kinase / transferase-transferase inhibitor complex |
---|
機能・相同性 | 機能・相同性情報
gamma-delta T cell activation / NK T cell differentiation / : / Generation of second messenger molecules / cellular defense response / T cell activation / FCERI mediated Ca+2 mobilization / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase ...gamma-delta T cell activation / NK T cell differentiation / : / Generation of second messenger molecules / cellular defense response / T cell activation / FCERI mediated Ca+2 mobilization / positive regulation of cytokine production / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / cell-cell junction / phosphorylation / T cell receptor signaling pathway / adaptive immune response / intracellular signal transduction / signal transduction / ATP binding / nucleus / metal ion binding / plasma membrane / cytosol類似検索 - 分子機能 Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain ...Tyrosine-protein kinase ITK, SH3 domain / Tyrosine-protein kinase ITK/TSK, catalytic domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 1.43 Å |
---|
データ登録者 | Han, S. / Caspers, N. |
---|
引用 | ジャーナル: J.Med.Chem. / 年: 2012 タイトル: Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay. 著者: Zapf, C.W. / Gerstenberger, B.S. / Xing, L. / Limburg, D.C. / Anderson, D.R. / Caspers, N. / Han, S. / Aulabaugh, A. / Kurumbail, R. / Shakya, S. / Li, X. / Spaulding, V. / Czerwinski, R.M. / ...著者: Zapf, C.W. / Gerstenberger, B.S. / Xing, L. / Limburg, D.C. / Anderson, D.R. / Caspers, N. / Han, S. / Aulabaugh, A. / Kurumbail, R. / Shakya, S. / Li, X. / Spaulding, V. / Czerwinski, R.M. / Seth, N. / Medley, Q.G. |
---|
履歴 | 登録 | 2012年10月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2012年11月14日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2013年1月2日 | Group: Database references |
---|
改定 1.2 | 2024年3月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / software / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _software.name / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|