登録情報 | データベース: PDB / ID: 4dku |
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タイトル | Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-09027 |
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要素 | HIV-1 gp120 core |
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キーワード | HYDROLASE / HIV-1 gp120 / clade A/E / CD4 mimic / NBD-09027 |
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機能・相同性 | 機能・相同性情報
positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / viral protein processing / fusion of virus membrane with host plasma membrane / virus-mediated perturbation of host defense response / fusion of virus membrane with host endosome membrane / viral envelope ...positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / viral protein processing / fusion of virus membrane with host plasma membrane / virus-mediated perturbation of host defense response / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / structural molecule activity / virion membrane / plasma membrane類似検索 - 分子機能 HIV Envelope Protein Gp120; Chain G / Human immunodeficiency virus 1, Gp160, envelope glycoprotein / Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Envelope glycoprotein GP120 / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Beta Complex / Mainly Beta類似検索 - ドメイン・相同性 Chem-0KU / clade A/E 93TH057 HIV-1 gp120 core / Envelope glycoprotein gp160類似検索 - 構成要素 |
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生物種 | ![](img/tx_virus.gif) Human immunodeficiency virus 1 (ヒト免疫不全ウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.4902 Å |
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データ登録者 | Kwon, Y.D. / Debnath, A.K. / Kwong, P.D. |
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引用 | ジャーナル: Antimicrob. Agents Chemother. / 年: 2014 タイトル: Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study. 著者: Curreli, F. / Kwon, Y.D. / Zhang, H. / Yang, Y. / Scacalossi, D. / Kwong, P.D. / Debnath, A.K. |
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履歴 | 登録 | 2012年2月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年3月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年8月2日 | Group: Database references / Source and taxonomy / カテゴリ: citation / citation_author / entity_src_gen Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2017年11月15日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2020年7月29日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.4 | 2021年5月19日 | Group: Source and taxonomy / Structure summary / カテゴリ: chem_comp / entity_src_gen Item: _chem_comp.pdbx_synonyms / _entity_src_gen.host_org_common_name ..._chem_comp.pdbx_synonyms / _entity_src_gen.host_org_common_name / _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_strain |
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改定 1.5 | 2023年9月13日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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