Entry Database : PDB / ID : 4dc2 Structure visualization Downloads & linksTitle Structure of PKC in Complex with a Substrate Peptide from Par-3 ComponentsPartitioning defective 3 homolog Protein kinase C iota type DetailsKeywords TRANSFERASE/TRANSFERASE SUBSTRATE / Kinase / substrate / Cell polarity / Par-3 / atypical PKC / TRANSFERASE-TRANSFERASE SUBSTRATE complexFunction / homology Function and homology informationFunction Domain/homology Component
Pre-NOTCH Transcription and Translation / Tight junction interactions / Tight junction interactions / regulation of actin filament-based process / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / internode region of axon / regulation of cellular localization / calcium,diacylglycerol-dependent serine/threonine kinase activity / Golgi vesicle budding / PAR polarity complex ... Pre-NOTCH Transcription and Translation / Tight junction interactions / Tight junction interactions / regulation of actin filament-based process / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / internode region of axon / regulation of cellular localization / calcium,diacylglycerol-dependent serine/threonine kinase activity / Golgi vesicle budding / PAR polarity complex / protein localization => GO:0008104 / p75NTR recruits signalling complexes / apical constriction / establishment of apical/basal cell polarity / establishment of centrosome localization / protein kinase C / negative regulation of glial cell apoptotic process / diacylglycerol-dependent serine/threonine kinase activity / positive regulation of myelination / lateral loop / establishment of epithelial cell polarity / eye photoreceptor cell development / Schmidt-Lanterman incisure / myelination in peripheral nervous system / bicellular tight junction assembly / cell-cell junction organization / phosphatidylinositol-3-phosphate binding / establishment or maintenance of epithelial cell apical/basal polarity / positive regulation of endothelial cell apoptotic process / protein targeting to membrane / wound healing, spreading of cells / centrosome localization / apical junction complex / establishment of cell polarity / intercellular bridge / negative regulation of peptidyl-threonine phosphorylation / cell leading edge / regulation of postsynaptic membrane neurotransmitter receptor levels / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of receptor internalization / bicellular tight junction / endomembrane system / axonal growth cone / positive regulation of glial cell proliferation / phosphatidylinositol-4,5-bisphosphate binding / phosphatidylinositol binding / response to interleukin-1 / actin filament organization / phospholipid binding / positive regulation of protein localization to plasma membrane / adherens junction / positive regulation of glucose import / Schaffer collateral - CA1 synapse / protein localization / positive regulation of neuron projection development / spindle / response to peptide hormone / microtubule cytoskeleton organization / cellular response to insulin stimulus / microtubule cytoskeleton / cell-cell junction / cell migration / apical part of cell / cell junction / positive regulation of NF-kappaB transcription factor activity / cell cortex / protein phosphatase binding / peptidyl-serine phosphorylation / negative regulation of neuron apoptotic process / cell adhesion / endosome / protein kinase activity / intracellular signal transduction / cell cycle / apical plasma membrane / cell division / Golgi membrane / protein phosphorylation / protein serine/threonine kinase activity / neuronal cell body / glutamatergic synapse / protein-containing complex / ATP binding / identical protein binding / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Atypical protein kinase C iota type, catalytic domain / Protein kinase C / Protein kinase C, PB1 domain / Par3/HAL, N-terminal / N-terminal of Par3 and HAL proteins / PB1 domain / PB1 domain / PB1 domain profile. / PB1 domain / Protein kinase, C-terminal ... Atypical protein kinase C iota type, catalytic domain / Protein kinase C / Protein kinase C, PB1 domain / Par3/HAL, N-terminal / N-terminal of Par3 and HAL proteins / PB1 domain / PB1 domain / PB1 domain profile. / PB1 domain / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.4 Å DetailsAuthors Shang, Y. / Wang, C. / Yu, J. / Zhang, M. CitationJournal : Structure / Year : 2012Title : Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKC iota in complex with a substrate peptide from Par-3Authors : Wang, C. / Shang, Y. / Yu, J. / Zhang, M. History Deposition Jan 17, 2012 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Jul 11, 2012 Provider : repository / Type : Initial release