登録情報 | データベース: PDB / ID: 4c79 |
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タイトル | Crystal structure of the Smoothened CRD, native |
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要素 | SMOOTHENED |
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キーワード | SIGNALING PROTEIN |
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機能・相同性 | 機能・相同性情報
somatic motor neuron differentiation / caudal fin morphogenesis / endocrine system development / angioblast cell migration from lateral mesoderm to midline / swim bladder development / swim bladder morphogenesis / neural plate pattern specification / epithelial tube formation / Hedgehog 'off' state / : ...somatic motor neuron differentiation / caudal fin morphogenesis / endocrine system development / angioblast cell migration from lateral mesoderm to midline / swim bladder development / swim bladder morphogenesis / neural plate pattern specification / epithelial tube formation / Hedgehog 'off' state / : / : / neural plate morphogenesis / otolith morphogenesis / floor plate formation / muscle cell fate commitment / semicircular canal morphogenesis / diencephalon development / habenula development / spinal cord motor neuron cell fate specification / forebrain dorsal/ventral pattern formation / arterial endothelial cell fate commitment / striated muscle cell development / cardioblast differentiation / embryonic neurocranium morphogenesis / glial cell development / dorsal aorta morphogenesis / embryonic viscerocranium morphogenesis / adenohypophysis development / myofibril assembly / embryonic camera-type eye development / endocardial cell differentiation / cardiac ventricle development / spinal cord motor neuron differentiation / telencephalon development / embryonic digestive tract morphogenesis / somite development / patched binding / hindbrain development / neuron fate commitment / endocrine pancreas development / cerebellum morphogenesis / smooth muscle tissue development / oligodendrocyte development / pattern specification process / embryonic pattern specification / exocrine pancreas development / commissural neuron axon guidance / oxysterol binding / positive regulation of smoothened signaling pathway / pancreas development / cartilage development / neural crest cell differentiation / muscle organ development / anterior/posterior pattern specification / inner ear morphogenesis / smoothened signaling pathway / retinal ganglion cell axon guidance / receptor clustering / heart looping / protein kinase A catalytic subunit binding / inner ear development / vasculogenesis / skeletal muscle fiber development / forebrain development / protein sequestering activity / negative regulation of protein phosphorylation / central nervous system development / axon guidance / G protein-coupled receptor activity / neuron differentiation / cilium / retina development in camera-type eye / nervous system development / dendrite / plasma membrane類似検索 - 分子機能 Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / Smoothened, transmembrane domain / Smoothened, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain ...Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / Smoothened, transmembrane domain / Smoothened, cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_fish.gif) DANIO RERIO (ゼブラフィッシュ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.604 Å |
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データ登録者 | Nachtergaele, S. / Whalen, D.M. / Mydock, L.K. / Zhao, Z. / Malinauskas, T. / Krishnan, K. / Ingham, P.W. / Covey, D.F. / Rohatgi, R. / Siebold, C. |
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引用 | ジャーナル: Elife / 年: 2013 タイトル: Structure and Function of the Smoothened Extracellular Domain in Vertebrate Hedgehog Signaling 著者: Nachtergaele, S. / Whalen, D.M. / Mydock, L.K. / Zhao, Z. / Malinauskas, T. / Krishnan, K. / Ingham, P.W. / Covey, D.F. / Siebold, C. / Rohatgi, R. |
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履歴 | 登録 | 2013年9月20日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2013年11月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年11月13日 | Group: Database references |
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改定 1.2 | 2023年12月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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