Entry Database : PDB / ID : 4b7y Structure visualization Downloads & linksTitle Crystal structure of the MSL1-MSL2 complex ComponentsMALE-SPECIFIC LETHAL 1 HOMOLOG MALE-SPECIFIC LETHAL 2 HOMOLOG DetailsKeywords GENE REGULATION / DOSAGE COMPENSATION / CHROMATINFunction / homology Function and homology informationFunction Domain/homology Component
MSL complex / Transferases; Acyltransferases; Aminoacyltransferases / ubiquitin protein ligase activity / HATs acetylate histones / protein ubiquitination / nuclear speck / chromatin remodeling / chromatin binding / positive regulation of DNA-templated transcription / nucleoplasm ... MSL complex / Transferases; Acyltransferases; Aminoacyltransferases / ubiquitin protein ligase activity / HATs acetylate histones / protein ubiquitination / nuclear speck / chromatin remodeling / chromatin binding / positive regulation of DNA-templated transcription / nucleoplasm / nucleus / metal ion binding Similarity search - Function Protein male-specific lethal-1 / Protein male-specific lethal-1, dimerisation domain / E3 ubiquitin-protein ligase Msl2, zinc RING finger / E3 ubiquitin-protein ligase Msl2, CXC domain / E3 ubiquitin-protein ligase MSL2 / CXC domain of E3 ubiquitin-protein ligase MSL2 / zinc RING finger of MSL2 / Dimerisation domain of Male-specific-Lethal 1 / PEHE domain / PEHE domain ... Protein male-specific lethal-1 / Protein male-specific lethal-1, dimerisation domain / E3 ubiquitin-protein ligase Msl2, zinc RING finger / E3 ubiquitin-protein ligase Msl2, CXC domain / E3 ubiquitin-protein ligase MSL2 / CXC domain of E3 ubiquitin-protein ligase MSL2 / zinc RING finger of MSL2 / Dimerisation domain of Male-specific-Lethal 1 / PEHE domain / PEHE domain / PEHE / Tesmin/TSO1-like CXC domain / Tesmin/TSO1-like CXC domain / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.25 Å DetailsAuthors Hallacli, E. / Lipp, M. / Georgiev, P. / Spielman, C. / Cusack, S. / Akhtar, A. / Kadlec, J. CitationJournal : Mol.Cell / Year : 2012Title : Msl1-Mediated Dimerization of the Dosage Compensation Complex is Essential for Male X-Chromosome Regulation in Drosophila.Authors : Hallacli, E. / Lipp, M. / Georgiev, P. / Spielman, C. / Cusack, S. / Akhtar, A. / Kadlec, J. History Deposition Aug 24, 2012 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 6, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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