登録情報 | データベース: PDB / ID: 4apd |
---|
タイトル | Liraglutide |
---|
要素 | Glucagon-like peptide 1(7-37) |
---|
キーワード | HORMONE / GLUCAGON / GLUCAGON LIKE PEPTIDE-1 ANALOG |
---|
機能・相同性 | 機能・相同性情報
glucagon receptor binding / protein kinase A signaling / negative regulation of execution phase of apoptosis / feeding behavior / positive regulation of calcium ion import / Synthesis, secretion, and deacylation of Ghrelin / positive regulation of insulin secretion involved in cellular response to glucose stimulus / positive regulation of gluconeogenesis / cellular response to glucagon stimulus / regulation of insulin secretion ...glucagon receptor binding / protein kinase A signaling / negative regulation of execution phase of apoptosis / feeding behavior / positive regulation of calcium ion import / Synthesis, secretion, and deacylation of Ghrelin / positive regulation of insulin secretion involved in cellular response to glucose stimulus / positive regulation of gluconeogenesis / cellular response to glucagon stimulus / regulation of insulin secretion / response to activity / gluconeogenesis / hormone activity / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / Glucagon signaling in metabolic regulation / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Glucagon-type ligand receptors / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / glucose homeostasis / secretory granule lumen / G alpha (s) signalling events / G alpha (q) signalling events / positive regulation of ERK1 and ERK2 cascade / G protein-coupled receptor signaling pathway / receptor ligand activity / endoplasmic reticulum lumen / signaling receptor binding / negative regulation of apoptotic process / extracellular space / extracellular region / identical protein binding / plasma membrane類似検索 - 分子機能 Glucagon / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones類似検索 - ドメイン・相同性 N-hexadecanoyl-L-glutamic acid / Pro-glucagon類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 溶液NMR |
---|
データ登録者 | Ludvigsen, S. / Steensgaard, D.B. / Thomsen, J.K. / Strauss, H. / Normann, M. |
---|
引用 | ジャーナル: To be Published タイトル: Liraglutide 著者: Steensgaard, D.B. / Thomsen, J.K. / Strauss, H. / Normann, M. / Ludvigsen, S. |
---|
履歴 | 登録 | 2012年4月2日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2013年7月10日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2014年1月29日 | Group: Database references / Source and taxonomy / Structure summary |
---|
改定 2.0 | 2023年6月14日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations / Other カテゴリ: atom_site / database_2 ...atom_site / database_2 / pdbx_database_status / pdbx_nmr_software / struct_conn / struct_site Item: _atom_site.Cartn_x / _atom_site.Cartn_y ..._atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.label_atom_id / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_cs / _pdbx_database_status.status_code_mr / _pdbx_database_status.status_code_nmr_data / _pdbx_nmr_software.name / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
改定 2.1 | 2024年11月6日 | Group: Data collection / Database references / Structure summary カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature Item: _database_2.pdbx_DOI / _pdbx_entry_details.has_protein_modification |
---|
改定 3.0 | 2025年5月21日 | Group: Atomic model / Database references ...Atomic model / Database references / Source and taxonomy / Structure summary カテゴリ: atom_site / entity ...atom_site / entity / entity_name_com / entity_src_gen / struct_ref / struct_ref_seq_dif Item: _atom_site.Cartn_x / _atom_site.Cartn_y ..._atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_atom_id / _atom_site.label_atom_id / _entity.pdbx_description / _entity_name_com.name / _entity_src_gen.gene_src_common_name / _entity_src_gen.pdbx_beg_seq_num / _entity_src_gen.pdbx_end_seq_num / _entity_src_gen.pdbx_gene_src_gene / _entity_src_gen.pdbx_gene_src_scientific_name / _entity_src_gen.pdbx_seq_type / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq_dif.details |
---|
|
---|
Remark 650 | HELIX DETERMINATION METHOD: AUTHOR PROVIDED. |
---|