登録情報 | データベース: PDB / ID: 3u86 |
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タイトル | Crystal structure of human menin in complex with JunD |
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要素 | - Menin
- Transcription factor jun-D
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キーワード | TRANSCRIPTION / menin / MEN1 / MLL / JunD / LEDGF / TPR / epigenetics / cancer |
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機能・相同性 | 機能・相同性情報
transcription factor AP-1 complex / Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / NGF-stimulated transcription / MLL1/2 complex / T-helper 2 cell differentiation / osteoblast development / histone methyltransferase complex ...transcription factor AP-1 complex / Y-form DNA binding / : / negative regulation of cyclin-dependent protein serine/threonine kinase activity / negative regulation of JNK cascade / NGF-stimulated transcription / MLL1/2 complex / T-helper 2 cell differentiation / osteoblast development / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / positive regulation of transforming growth factor beta receptor signaling pathway / R-SMAD binding / cleavage furrow / MLL1 complex / negative regulation of cell cycle / RHO GTPases activate IQGAPs / negative regulation of osteoblast differentiation / positive regulation of osteoblast differentiation / response to UV / four-way junction DNA binding / transcription initiation-coupled chromatin remodeling / cellular response to calcium ion / transcription repressor complex / negative regulation of protein phosphorylation / transcription coregulator binding / Deactivation of the beta-catenin transactivating complex / response to gamma radiation / phosphoprotein binding / Post-translational protein phosphorylation / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / Formation of the beta-catenin:TCF transactivating complex / negative regulation of DNA-binding transcription factor activity / nuclear matrix / RNA polymerase II transcription regulator complex / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / MAPK cascade / sequence-specific double-stranded DNA binding / protein-macromolecule adaptor activity / regulation of cell population proliferation / gene expression / double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / transcription regulator complex / chromosome, telomeric region / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / regulation of cell cycle / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of cell population proliferation / endoplasmic reticulum lumen / DNA repair / negative regulation of DNA-templated transcription / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / enzyme binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Transcription factor Jun / Jun-like transcription factor / Jun-like transcription factor / bZIP transcription factor / Menin / Transcription factor, Skn-1-like, DNA-binding domain superfamily / Menin / Basic-leucine zipper (bZIP) domain signature. / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper ...Transcription factor Jun / Jun-like transcription factor / Jun-like transcription factor / bZIP transcription factor / Menin / Transcription factor, Skn-1-like, DNA-binding domain superfamily / Menin / Basic-leucine zipper (bZIP) domain signature. / Basic-leucine zipper (bZIP) domain profile. / basic region leucin zipper / Basic-leucine zipper domain superfamily / Basic-leucine zipper domain類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.843 Å |
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データ登録者 | Huang, J. / Wan, B. / Lei, M. |
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引用 | ジャーナル: Nature / 年: 2012 タイトル: The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. 著者: Huang, J. / Gurung, B. / Wan, B. / Matkar, S. / Veniaminova, N.A. / Wan, K. / Merchant, J.L. / Hua, X. / Lei, M. |
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履歴 | 登録 | 2011年10月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年2月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年3月7日 | Group: Database references |
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改定 1.2 | 2017年6月21日 | Group: Database references / Source and taxonomy / Structure summary カテゴリ: entity_src_gen / pdbx_entry_details ...entity_src_gen / pdbx_entry_details / struct_ref / struct_ref_seq / struct_ref_seq_dif Item: _struct_ref.db_code / _struct_ref.db_name ..._struct_ref.db_code / _struct_ref.db_name / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref.pdbx_db_isoform / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_ref_seq.pdbx_db_accession / _struct_ref_seq.seq_align_end |
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改定 1.3 | 2017年11月8日 | Group: Refinement description / カテゴリ: software |
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改定 1.4 | 2024年2月28日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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