登録情報 データベース : PDB / ID : 3r2f 構造の表示 ダウンロードとリンクタイトル Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with BMS-693391 AKA (2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-((2R,4R)-4-propoxy-2-pyrrolidinyl)ethyl)-4-phenylbutanamide 要素Beta-secretase 1 詳細 キーワード HYDROLASE/HYDROLASE INHIBITOR / Alzheimer's Disease / aspartic protease / beta-secretase / memapsin 2 / HYDROLASE-HYDROLASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.53 Å 詳細データ登録者 Muckelbauer, J.K. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2011タイトル : Monosubstituted {gamma}-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of {beta}-secretase (BACE).著者: Boy, K.M. / Guernon, J.M. / Shi, J. / Toyn, J.H. / Meredith, J.E. / Barten, D.M. / Burton, C.R. / Albright, C.F. / Marcinkeviciene, J. / Good, A.C. / Tebben, A.J. / Muckelbauer, J.K. / Camac, ... 著者 : Boy, K.M. / Guernon, J.M. / Shi, J. / Toyn, J.H. / Meredith, J.E. / Barten, D.M. / Burton, C.R. / Albright, C.F. / Marcinkeviciene, J. / Good, A.C. / Tebben, A.J. / Muckelbauer, J.K. / Camac, D.M. / Lentz, K.A. / Bronson, J.J. / Olson, R.E. / Macor, J.E. / Thompson, L.A. 履歴 登録 2011年3月14日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2011年8月31日 Provider : repository / タイプ : Initial release改定 1.1 2013年6月19日 Group : Database references改定 1.2 2019年7月17日 Group : Data collection / Refinement description / カテゴリ : softwareItem : _software.classification / _software.name / _software.version
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