Entry Database : PDB / ID : 3lnm Structure visualization Downloads & linksTitle F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel ComponentsF233W mutant of the Kv2.1 paddle-Kv1.2 chimera Voltage-gated potassium channel subunit beta-2 DetailsKeywords MEMBRANE PROTEIN / TRANSPORT PROTEIN / voltage-gated potassium channel-beta subunit complex / Acetylation / Cytoplasm / Ion transport / Ionic channel / NADP / Phosphoprotein / Potassium / Potassium transport / Transport / Voltage-gated channel / Glycoprotein / Lipoprotein / Membrane / Palmitate / Potassium channel / TransmembraneFunction / homology Function and homology informationFunction Domain/homology Component
optic nerve structural organization / pinceau fiber / regulation of action potential / clustering of voltage-gated potassium channels / positive regulation of long-term synaptic depression / regulation of motor neuron apoptotic process / Voltage gated Potassium channels / voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / potassium channel complex / positive regulation of norepinephrine secretion ... optic nerve structural organization / pinceau fiber / regulation of action potential / clustering of voltage-gated potassium channels / positive regulation of long-term synaptic depression / regulation of motor neuron apoptotic process / Voltage gated Potassium channels / voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / potassium channel complex / positive regulation of norepinephrine secretion / NADPH oxidation / positive regulation of catecholamine secretion / paranodal junction / potassium ion export across plasma membrane / proximal dendrite / positive regulation of calcium ion-dependent exocytosis / regulation of circadian sleep/wake cycle, non-REM sleep / cholinergic synapse / axon initial segment / regulation of protein localization to cell surface / delayed rectifier potassium channel activity / corpus callosum development / voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / aldo-keto reductase (NADPH) activity / vesicle docking involved in exocytosis / outward rectifier potassium channel activity / juxtaparanode region of axon / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / optic nerve development / postsynaptic specialization membrane / regulation of potassium ion transmembrane transport / glutamate receptor signaling pathway / Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor / myoblast differentiation / Neutrophil degranulation / response to L-glutamate / neuromuscular process / action potential / neuronal cell body membrane / regulation of dopamine secretion / voltage-gated potassium channel activity / cellular response to nutrient levels / lamellipodium membrane / kinesin binding / neuronal action potential / calyx of Held / positive regulation of protein targeting to membrane / response to axon injury / potassium channel regulator activity / lateral plasma membrane / negative regulation of insulin secretion / hematopoietic progenitor cell differentiation / voltage-gated potassium channel complex / axon terminus / sensory perception of pain / potassium ion transmembrane transport / dendrite membrane / cellular response to calcium ion / extrinsic component of cytoplasmic side of plasma membrane / SNARE binding / protein localization to plasma membrane / cellular response to glucose stimulus / postsynaptic density membrane / sarcolemma / protein homooligomerization / potassium ion transport / cytoplasmic side of plasma membrane / cerebral cortex development / glucose homeostasis / presynaptic membrane / lamellipodium / perikaryon / postsynaptic membrane / transmembrane transporter binding / postsynaptic density / cytoskeleton / endosome / neuron projection / apical plasma membrane / protein heterodimerization activity / axon / dendrite / neuronal cell body / glutamatergic synapse / protein-containing complex binding / endoplasmic reticulum membrane / perinuclear region of cytoplasm / cell surface / membrane / plasma membrane / cytosol Similarity search - Function Potassium channel, voltage dependent, Kv2.1 / Potassium channel, voltage dependent, Kv2 / Potassium channel, voltage dependent, Kv1.2 / Kv2 voltage-gated K+ channel / Potassium channel, voltage-dependent, beta subunit, KCNAB2 / Potassium channel, voltage-dependent, beta subunit, KCNAB / Potassium channel, voltage-dependent, beta subunit, KCNAB-related / Voltage-gated potassium channels. Chain C / Potassium channel, voltage dependent, Kv1 / Potassium channel, voltage dependent, Kv ... Potassium channel, voltage dependent, Kv2.1 / Potassium channel, voltage dependent, Kv2 / Potassium channel, voltage dependent, Kv1.2 / Kv2 voltage-gated K+ channel / Potassium channel, voltage-dependent, beta subunit, KCNAB2 / Potassium channel, voltage-dependent, beta subunit, KCNAB / Potassium channel, voltage-dependent, beta subunit, KCNAB-related / Voltage-gated potassium channels. Chain C / Potassium channel, voltage dependent, Kv1 / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / Helix Hairpins - #70 / NADP-dependent oxidoreductase domain / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Voltage-dependent channel domain superfamily / SKP1/BTB/POZ domain superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / Ion transport domain / Ion transport protein / Helix Hairpins / TIM Barrel / Alpha-Beta Barrel / Up-down Bundle / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homology : / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Chem-PGW / Potassium voltage-gated channel subfamily B member 1 / Voltage-gated potassium channel subunit beta-2 / Potassium voltage-gated channel subfamily A member 2 Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / isomorphous to the wild-type structure / Resolution : 2.9 Å DetailsAuthors Tao, X. / Lee, A. / Limapichat, W. / Dougherty, D.A. / MacKinnon, R. CitationJournal : Science / Year : 2010Title : A gating charge transfer center in voltage sensors.Authors : Tao, X. / Lee, A. / Limapichat, W. / Dougherty, D.A. / MacKinnon, R. History Deposition Feb 2, 2010 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 14, 2010 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Aug 2, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.3 Oct 13, 2021 Group : Database references / Derived calculationsCategory : database_2 / pdbx_struct_conn_angle ... database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.4 Sep 6, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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