- PDB-3l8n: Crystal Structure of a domain of Brefeldin A-inhibited guanine nu... -
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Basic information
Entry
Database: PDB / ID: 3l8n
Title
Crystal Structure of a domain of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BrefeldinA-inhibited GEP 2) from Homo sapiens (Human). Northeast Structural Genomics Consortium target id HR5562A
Components
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Keywords
Nucleotide-binding protein / Metal-binding protein / Structural Genomics / PSI-2 / Protein Structure Initiative / Northeast Structural Genomics Consortium / NESG / Guanine-nucleotide releasing factor / Phosphoprotein
Function / homology
Function and homology information
endomembrane system organization / symmetric synapse / receptor recycling / axonemal microtubule / endosome organization / GABA receptor binding / Golgi to plasma membrane transport / regulation of ARF protein signal transduction / microtubule organizing center / myosin binding ...endomembrane system organization / symmetric synapse / receptor recycling / axonemal microtubule / endosome organization / GABA receptor binding / Golgi to plasma membrane transport / regulation of ARF protein signal transduction / microtubule organizing center / myosin binding / protein kinase A regulatory subunit binding / exocytosis / Association of TriC/CCT with target proteins during biosynthesis / asymmetric synapse / GABA-ergic synapse / guanyl-nucleotide exchange factor activity / trans-Golgi network / recycling endosome / positive regulation of tumor necrosis factor production / protein transport / presynapse / cytoplasmic vesicle / dendritic spine / intracellular signal transduction / Golgi membrane / intracellular membrane-bounded organelle / centrosome / glutamatergic synapse / perinuclear region of cytoplasm / Golgi apparatus / membrane / cytosol Similarity search - Function
Resolution: 2.8→2.91 Å / Redundancy: 1.9 % / Rmerge(I) obs: 0.343 / Rsym value: 0.29 / % possible all: 99.3
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Processing
Software
Name
Version
Classification
ADSC
Quantum
datacollection
SHELXS
phasing
CNS
1.2
refinement
HKL-2000
datareduction
HKL-2000
datascaling
Refinement
Method to determine structure: SAD / Resolution: 2.86→17.65 Å / Rfactor Rfree error: 0.012 / Data cutoff high absF: 306158.18 / Data cutoff low absF: 0 / Isotropic thermal model: RESTRAINED / Cross valid method: THROUGHOUT / σ(F): 2 / Stereochemistry target values: Engh & Huber Details: BULK SOLVENT MODEL USED. The data is twined with twinning operator= -h,-k,l and twinning fraction= 0.321.
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